Pyrazine derivatives with extended conjugation and methods of using the same in optical applications
AssigneeMediBeacon Inc.
InventorsWilliam L. Neumann, Raghavan Rajagopalan, Richard B. Dorshow
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Abstract
The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically acceptable composition and utilized in medical (e.g., diagnostic imaging) procedures.
Claims21
1-97. (canceled)
A compound of Formula (2), or a pharmaceutically acceptable salt thereof, for optically assessing a physiological function in a patient in need thereof;
- wherein
- EWG is an electron withdrawing group;
- EDG is an electron donating group;
- x and y are each independently from the other 1, 2 or 3, and the sum of x and y is 3 or 4;
- and
- at least one of EWG and EDG is conjugated to the pyrazine ring through a chemically unsaturated linking group.
A pharmaceutical formulation for optically assessing a physiological function in a patient in need thereof;
- the formulation comprising:
- a compound according to Formula (2), or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient;
- wherein
- EWG is an electron withdrawing group;
- EDG is an electron donating group;
- x and y are each independently from the other 1, 2 or 3, and the sum of x and y is 3 or 4;
- and
- at least one of EWG and EDG is conjugated to the pyrazine ring through a chemically unsaturated linking group.
Dependencies are inferred from the claim text.