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US 2019/0194156 A1Published application
Method of producing beraprost
AssigneeLung Biotechnology PBC
InventorsVijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Abstract
An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
Claims19
1-20. (canceled)
A method of synthesizing a substantially pure salt of beraprost stereoisomer comprising converting an R1 group in a substantially pure ester compound of the following formula:
- into a cation to form the substantially pure salt of beraprost stereoisomer, wherein R1 is initially a C1-12 alkyl, each of R2 and R3 is H, and each of R4 and R5 is CH3.
Dependencies are inferred from the claim text.