Crystal forms of valsartan disodium salt
AssigneeNoratech Pharmaceuticals, Inc.
InventorsFei LIU, Gang WU, Weiming JIANG, Cheng-Gang LIN, Xuan CAI, Ping LIN, Yuling LU, Lixiang LIU
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Abstract
Provided are crystal forms A, B, D, E, F, G and H of valsartan disodium salt and a preparation method therefor.
Claims26
A crystalline form A of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.7±0.2, 8.5±0.2, 9.5±0.2, 13.6±0.2, 15.4±0.2, 16.5±0.2, 18.1±0.2, 19.9±0.2, 22.0±0.2, 22.4±0.2, 23.3±0.2, 23.8±0.2, 25.3±0.2, and 27.8±0.2, expressed in degrees 2θ.
A crystalline form B of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.4±0.2 and 8.8±0.2, expressed in degree 2θ.
A crystalline form D of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.4±0.2, 9.0±0.2, 14.9±0.2, 21.4±0.2, and 22.4±0.2, expressed in degrees 2θ.
A crystalline form E of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 6.3±0.2, 12.3±0.2, 14.7±0.2, 16.5±0.2, and 17.4±0.2, expressed in degrees 2θ.
A crystalline form F of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 6.2±0.2, 14.9±0.2, and 18.3±0.2, expressed in degrees 2θ.
A crystalline form G of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 6.4±0.2, 8.3±0.2, 9.5±0.2, 17.3±0.2, and 19.4±0.2, expressed in degrees 2θ.
A crystalline form H of valsartan disodium salt, wherein, the crystalline form has the following properties:
- by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.5±0.2, 8.7±0.2, and 9.0±0.2, expressed in degrees 2θ.
Dependencies are inferred from the claim text.