An adenosine monophosphate-activated protein kinase agonist
AssigneeFarmar Licensing Co., Ltd.
InventorsChung-Wai SHIAU, Jung-Chen SU, Yan-Ju LIN, Jui-Wen HUANG
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Abstract
The present invention discloses a compound of the formula (I), which acts as an agonist of adenosine monophosphate-activated protein kinase, which induce phosphorylation and activation of AMPKα, thereby further regulating downstream signaling pathways, inhibiting growth and proliferation of liver cancer cells and breast cancer cells, and also inducing apoptosis of adipocytes. Therefore, the compound provided by the present invention can be utilised for treatment and preparation of pharmaceutical composition for cancer, and lipid metabolism-related diseases or syndromes mediated by AMPK.
Claims19
A compound of the formula (I):
- or a pharmaceutically acceptable salt thereof, wherein R1 is an unsubstituted or substituted aromatic group;
- R3 is a substituted phenyl amide group or a substituted phenyl urea group;
- Ar is an unsubstituted or substituted phenylene group.
Dependencies are inferred from the claim text.