7H- azulene [1,2,3-i,j] isoquinolin-7-one compound, single crystal and use thereof
AssigneeHunan University of Chinese Medicine
InventorsShunxiang Li, Juan Li
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Abstract
A 7H-azulene [1,2,3-i,j] isoquinolin-7-one compound, a single crystal and a use thereof are provided. The compound has a structure as shown in a formula (I). The present invention obtains a crude extract of Acorus calamus L., then extracts with different polar solvents in sequence and separates column chromatography to obtain a novel alkaloid compound, which is expected to be developed into a novel class of drug exerting neuroprotective effects, so as to prevent and treat senile dementia, stroke and epilepsy diseases.
Claims10
A class of compounds having a mother nucleus structure of 7H-azulene [1,2,3-i,j] isoquinolin-7-one, which are the compounds as shown in a formula (I);
- or stereoisomer, oxynitride, pharmaceutically acceptable salt or prodrug of the compounds as shown in the formula (I):
- wherein,
- each of R1, R2 and R3 is independently hydrogen, hydrazine, F, Cl, Br, I, hydroxy, amino, nitro, cyano, C1-6 alkyl, hydroxy C1-6 alkyl, amino C1-6 alkyl , C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkoxy C1-6 alkyl, C2-6 alkenyl, alkynyl, C1-6 alkylamino, or C1-6 alkoxy;
- or carbon atoms attached between R1 and R2 together form an oxygen-containing C2-7 heterocycle.
A single crystal of a compound as shown in a formula (II), wherein the single crystal has following single crystal structure parameters:
- crystal system
- monoclinic system
- space group
- P121/c1
- cell parameters
- a = 7.5352(8) Å, α = 90°,
- b = 11.7589(10) Å, β = 95.301(6)°,
- c = 15.6709(14) Å, γ = 90°,
- volume
- 1382.6(2) Å3
- number of molecules per
- 4
- unit cell Z:
A method for preparing a compound as shown in a formula (II), comprising steps of:
- washing rhizomes of Acorus calamus L. for removing impurities, drying in shade, pulverizing into coarse powder, extracting with an alcohol solvent, and concentrating an extract under a reduced pressure until the extract is viscous, so as to obtain an alcohol extract;
- suspending the alcohol extract in water, extracting with different polar solvents in sequence, concentrating a solvent extract under a reduced pressure;
- and separating residue by column chromatography to obtain the compound as shown in the formula (II).
Dependencies are inferred from the claim text.