Methods for treating attention-deficit/hyperactivity disorder
AssigneeSK Biopharmaceuticals Co., Ltd.
InventorsSung James Lee, Susan Marie Melnick
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Abstract
The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
Claims17
A method of treating ADHD, comprising the administration of a therapeutically effective amount of a compound having structural Formula (1) or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment:
- wherein
- R is selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro group, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms;
- x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3;
- R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms;
- R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the heterocyclic compound comprises 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
A pharmaceutical composition for comprising a compound having structural Formula (1) or a pharmaceutically acceptable salt thereof.
- wherein
- R is selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro group, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms;
- x is an integer of 1 to 3, with the proviso that R may be the same or different when x is ;2 or 3;
- R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms;
- R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the heterocyclic compound comprises 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
Dependencies are inferred from the claim text.