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US 2019/0194115 A1Published application
Synthesis of Azelaic Acid
AssigneePCI Synthesis, Inc.
InventorsRajesh Thamatam, Bishwabhusan Sahoo, Rajesh Shukla
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Abstract
This invention concerns a method of synthesizing Azelaic Acid. Particular reference is made to providing a new synthetic process for preparing azelaic acid in large scale with high purity (e.g., >99.7% with any individual impurity not more than 0.1%), which can be used as an active pharmaceutical ingredient.
Claims22
A process for manufacturing azelaic acid comprising the step of:
- (a) decarboxylating heptane-1,1,7,7-tetracarboxylic acid with an organic base;
- thereby forming azelaic acid.
(canceled)
11-20. (canceled)
A process for manufacturing azelaic acid comprising the step of:
- decarboxylating heptane-1,1,7,7-tetracarboxylic acid using triethylamine in toluene at a temperature of about 100° C. to about 110° C.;
- thereby forming azelaic acid.
Dependencies are inferred from the claim text.