Microparticulated Vaccines for the Oral or Nasal Vaccination and Boostering of Animals Including Fish
AssigneeIntervet Inc.
InventorsMordechai Harel, Brian Carpenter
Life of this patent
Estimating the term…
Abstract
The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.
Claims20
An immunogenic substance for oral or nasal vaccination comprising a vaccine, a cross-linked mucoadhesive polymer, 10-60 wt % of one or more sugars, 3-10 wt % of one or more oligosaccharides and 1-10 wt % of one or more electrolytes, wherein the immunogenic substance is prepared by a method comprising:
- (a) dissolving the mucoadhesive polymer and the one or more oligosaccharides in an aqueous solution;
- (b) mixing the vaccine with the resulting solution from step (a) to form a slurry;
- (c) cross-linking the mucoadhesive polymer in the slurry with the one or more electrolytes to form hydrogel particles;
- (d) soaking the hydrogel particles in a solution saturated with the one or more sugars to make semi-dry particles;
- and
- (e) drying the semi-dry particles to form the immunogenic substance.
Dependencies are inferred from the claim text.