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US 2019/0177295 A1Published application
Process for the preparation of a 1,3-disubstituted pyrazole compound
AssigneeVertex Pharmaceuticals Incorporated
InventorsCavan McKeon Bligh, John J. Court, Jianglin Liang, Hardwin O'Dowd, Stefanie Roeper, Michael P. Ryan
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Abstract
The disclosure provides a process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Claims29
A process for preparing a compound of formula (I)
- or a pharmaceutically acceptable salt thereof, comprising:
- reacting a compound of formula (II)
- with a compound of formula (III)
- in the presence of a suitable base to afford the compound of formula (I);
- and
- optionally reacting the compound of formula (I) with a suitable acid to afford a pharmaceutically acceptable salt of the compound of formula (I).
3 more elements
A process for preparing a compound of formula (I)
- or a pharmaceutically acceptable salt thereof, comprising:
- reacting a compound of formula (V)
- with a compound of formula (VI)
- in the presence of a suitable base to afford a compound of formula (IV)
- and transforming the compound of formula (IV) to the compound of formula (I), or a pharmaceutically acceptable salt thereof.
2 more elements
A process for preparing a compound of formula (I)
- comprising:
- reacting a compound of formula (II)
- with a compound of formula (III)
- in the presence of a suitable base to afford the compound of formula (I).
1 more element
A process for preparing a compound of formula (I)
- comprising:
- reacting a compound of formula (V)
- with a compound of formula (VI)
- in the presence of a suitable base to afford a compound of formula (IV)
- and transforming the compound of formula (IV) to the compound of formula (I).
2 more elements
A compound of formula (II)
A compound of formula (III)
A compound of formula (IV)
Dependencies are inferred from the claim text.