Compositions and Methods for Preventing and Treating Heterotopic Ossification and Pathologic Calcification

A method for preventing or treating heterotopic ossification, vascular calcification, or pathologic calcification, comprising administering a therapeutically effective amount of a combination of compounds selected from the group consisting of:

• a) a combination of a Hedgehog (Hh) pathway antagonist together with:
• i) vitamin D, cholecalciferol or a vitamin D analog;
• or
• ii) a statin;
• b) the combination of:
• i) vitamin D, cholecalciferol or a vitamin D analog;
• and
• ii) a statin;
• and
• c) the combination of:
• i) a Hh pathway antagonist;
• ii) vitamin D, cholecalciferol or a vitamin D analog;
• and
• iii) a statin.
• wherein the compounds of paragraphs a), b) and c), are administered in a co-timely manner.