# US 2019/0170775 A1 · Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices

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- Number: US 2019/0170775 A1
- Document ID: US20190170775A1
- Status: Published application
- Kind: A1
- Application number: 16/210,953
- Filed: 2018-12-05
- Published: 2019-06-06
- Earliest claimed: 2004-08-19
- Assignees: Blood Cell Storage, Inc.
- Applicants: Blood Cell Storage, Inc.
- Inventors: Michael W. Reed; Steven J. Geelhood; Paul C. Harris; Lynn M. Barker; Perry Hargrave; Oliver Z. Nanassy
- Web page: https://patentgrep.com/patent/US20190170775A1

## CPC

- G01N 33/84: involving inorganic compounds or pH
- C12Q 1/04: Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor {(C12Q1/6897 takes precedence)}
- C12Q 1/22: Testing for sterility conditions
- C12Q 1/54: involving glucose or galactose
- G01N 21/6428: {Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53)}
- G01N 21/77: by observing the effect on a chemical indicator
- G01N 21/80: Indicating pH value
- G01N 33/492: {Determining multiple analytes}
- G01N 33/542: with steric inhibition or signal modification, e.g. fluorescent quenching
- G01N 33/582: {with fluorescent label}
- G01N 33/66: involving blood sugars, e.g. galactose
- G01N 2021/6421: {Measuring at two or more wavelengths}
- G01N 2021/6434: {Optrodes}
- G01N 2021/6484: {Optical fibres}
- G01N 2021/7786: {Fluorescence}
- G01N 2201/062: LED's
- G01N 2201/068: Optics, miscellaneous
- G01N 2201/0826: Fibre array at source, distributing
- G01N 2201/084: Fibres for remote transmission
- G01N 2400/00: Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

## Claims

### Claim 1

A system, comprising:
(a) a plurality of sample-containing vessels positioned within an system, each vessel comprising a fluorescent species in the sample, wherein the fluorescent species has an emission that is dependent on a parameter to be measured; and
(b) a means for monitoring a parameter of one or more of the plurality of samples-containing vessels positioned in the system, the means comprising:
(i) a light source for exciting the fluorescent species;
(ii) an emission detector for measuring emission from the fluorescent species; and
(iii) a probe for delivering excitation light to the fluorescent species and for delivering emission light to the detector.

### Claim 2 (depends on 1)

The system of claim 1, wherein the system comprises a single probe.

### Claim 3 (depends on 1)

The system of claim 1, wherein the system comprises a separate probe for each vessel.

### Claim 4 (depends on 1)

The system of claim 1, wherein the parameter is pH.

### Claim 5 (depends on 1)

The system of claim 1, wherein the parameter is CO2.

### Claim 6 (depends on 1)

The system of claim 1, wherein the parameter is oxygen.

### Claim 7 (depends on 1)

The system of claim 1, wherein the parameter is glucose.

### Claim 8 (depends on 1)

The system of claim 1, wherein the fluorescent species has a first emission intensity at a first emission wavelength and a second emission intensity at a second emission wavelength, and wherein the first and second emission wavelengths are not the same.

### Claim 9 (depends on 1)

The system of claim 1 further comprising a housing for receiving a probe, wherein the housing is adapted for receiving the probe at a first end and terminating with a window at the second end, the window being transparent to excitation and emission light, and wherein the window physically isolates the probe from the fluorescent species.