# US 2019/0170747 A1 · The application of anaplasma phagocytophilum protein aph1384

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- Number: US 2019/0170747 A1
- Document ID: US20190170747A1
- Status: Published application
- Kind: A1
- Application number: 16/321,824
- Filed: 2017-06-12
- Published: 2019-06-06
- Earliest claimed: 2017-03-14
- Assignees: Soochow University
- Applicants: Soochow University
- Inventors: Hua NIU; Meiling HE; Shuyan WU
- Web page: https://patentgrep.com/patent/US20190170747A1

## CPC

- G01N 33/56911: {Bacteria}
- C07K 14/29: from Richettsiales (O)
- G01N 33/561: Immunoelectrophoresis
- G01N 33/56966: {Animal cells}
- G01N 33/68: involving proteins, peptides or amino acids {(involving lipoproteins G01N33/92)}
- G01N 2333/195: from bacteria
- G01N 2333/29: from Richettsiales (o)
- G01N 2333/43552: from insects
- G01N 2333/43556: from ticks
- G01N 2469/20: Detection of antibodies in sample from host which are directed against antigens from microorganisms
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention relates to use of an Anaplasma phagocytophilum protein APH1384 as diagnostic antigen for granulocytic anaplasmosis. The protein can remedy the drawback of missed detection of an existing diagnostic antigen P44 for granulocytic anaplasmosis, improve sensitivity of detection for granulocytic anaplasmosis, and facilitate rapid and accurate clinical diagnosis of granulocytic anaplasmosis.

## Claims

### Claim 1

Use of an Anaplasma phagocytophilum protein APH1384 as diagnostic antigen for granulocytic anaplasmosis.

### Claim 2 (depends on 1)

The use as claimed in claim 1, wherein the Anaplasma phagocytophilum protein APH1384 has an amino acid sequence shown in SEQ ID NO: 1.

### Claim 3 (depends on 1)

The use as claimed in claim 1, wherein an antigenic epitope of the Anaplasma phagocytophilum protein APH1384 has an amino acid sequence shown in SEQ ID NO: 2.