# US 2019/0170746 A1 · Mycobacterium Antigens

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- Number: US 2019/0170746 A1
- Document ID: US20190170746A1
- Status: Published application
- Kind: A1
- Application number: 16/026,590
- Filed: 2018-07-03
- Published: 2019-06-06
- Earliest claimed: 2007-11-10
- Assignees: The Secretary of State for Environment, Food and Rural Affairs
- Applicants: The Secretary of State for Environment, Food and Rural Affairs
- Inventors: Hans Martin Vordermeier; Benjamin Sidders; Neil Graham Stoker; Katie Ewer
- Web page: https://patentgrep.com/patent/US20190170746A1

## CPC

- G01N 33/5695: {Mycobacteria}
- C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68)
- C07K 14/35: from Mycobacteriaceae (F)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- A61K 39/02: Bacterial antigens
- A61K 39/04: Mycobacterium, e.g. Mycobacterium tuberculosis
- G01N 2333/35: from Mycobacteriaceae (F)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.

## Claims

### Claim 1

A diagnostic reagent for use in the detection of M. tuberculosis infection in an animal, comprising one or more peptides each consisting of one of SEQ ID NO:1-13, or a functional variant peptide having at least 90% sequence identity to and capable of eliciting a similar immune response to SEQ ID NO:1-13.