# US 2019/0169660 A1 · Eukaryotic microorganisms for producing lipids and antioxidants

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- Number: US 2019/0169660 A1
- Document ID: US20190169660A1
- Status: Published application
- Kind: A1
- Application number: 16/133,091
- Filed: 2018-09-17
- Published: 2019-06-06
- Earliest claimed: 2005-06-07
- Assignees: DSM Nutritional Products AG
- Applicants: Dsm Nutritional Products AG
- Inventors: Adam M BURJA; Helia RADIANINGTYAS; Colin James BARROW; Anthony James WINDUST
- Web page: https://patentgrep.com/patent/US20190169660A1

## CPC

- C12P 7/6434: Docosahexenoic acids [DHA]
- A21D 8/04: treating dough with microorganisms or enzymes
- A23K 10/18: of live microorganisms
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23L 29/065: {Microorganisms (addition of bacteria for nutritional purposes A23L33/135)}
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23P 10/30: Encapsulation of particles, e.g. foodstuff additives
- A61K 9/4875: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/4858)}
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 39/06: Free radical scavengers or antioxidants
- C12N 1/00: Microorganisms; Compositions thereof (medicinal preparations containing material from protozoa, bacteria or viruses A61K35/66, from algae A61K36/02, from fungi A61K36/06; preparing medicinal bacterial antigen or antibody compositions, e.g. bacterial vaccines, A61K39/00); Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12P 7/6427: Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P 7/6432: Eicosapentaenoic acids [EPA]
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- C12R 2001/00: Microorganisms {; Processes using microorganisms}
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- A21D: TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS (preservation of flour or dough before baking A23B40/00; preservation of bakery products A23B45/00)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A23P: SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

Disclosed are compositions and methods related to eukaryotic microorganisms that can produce unsaturated fatty acids which can be purified and used.

## Claims

### Claim at position 1

1-100. (canceled)

### Claim 101

A lipid composition comprising from 25 wt. % to 40 wt. % of n-3 DHA, from 6 wt. % to 10 wt. % n-6 DPA, and from 0 wt. % to 3 wt. % of n-3 EPA.

### Claim 102 (depends on 1)

The lipid composition of claim 1, wherein further comprising 11 wt. % to 15 wt. % of myristic acid.

### Claim 103 (depends on 1)

The lipid composition of claim 1, wherein further comprising 3 wt. % to 7 wt. % of palmitoleic acid.

### Claim 104 (depends on 1)

The lipid composition of claim 1, wherein further comprising at least 1 wt. % carotenoid material.

### Claim 105 (depends on 1, 2, 3, 4)

The lipid composition of any one of claims 1-4, wherein said lipid composition is derived from a eukaryotic microorganism Thraustochytrium sp.

### Claim 106 (depends on 1, 2, 3, 4, 5)

The lipid composition of any one of claims 1 to 5, wherein said lipid composition further comprising an effective amount of at least one added antioxidant to provide oxidative stability.

### Claim 107 (depends on 1, 2, 3, 4, 5, 6)

A food product, cosmetic, or pharmaceutical composition for animals or humans, comprising the lipid composition of any one of claims 1 to 6.

### Claim 108 (depends on 7)

The food product of claim 7, wherein the food product is an infant formula.

### Claim 109 (depends on 7)

The food product of claim 7, wherein the food product is milk, a beverage, a therapeutic drink, a nutritional drink, or a combination thereof.

### Claim 110 (depends on 7)

The food product of claim 7, wherein the food product is an additive for animal or human food.

### Claim 111 (depends on 7)

The food product of claim 7, wherein the food product is a nutritional supplement.

### Claim 112 (depends on 7)

The food product of claim 7, wherein the food product is an animal feed.

### Claim 113 (depends on 63)

The animal feed of claim 63, wherein the animal feed is an aquaculture feed.