Methods of Generating Recombinant Spider Silk Protein Fibers
OwnerMaxime Boulet-Audet, Gregory Wilson Rice +5inventors
InventorsMaxime Boulet-Audet, Gregory Wilson Rice, Krystle Marie Moody, Jamie McAusland Bainbridge, Steven Tom, Amir Ahmad Bakhtiary Davijani, Lindsay Wray
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Abstract
Provided herein are scalable methods of generating a recombinant silk polypeptide with a coefficient of friction sufficient to form mechanical interactions with other fibers.
Claims37
A plurality of fibers comprising recombinant spider silk polypeptide, wherein the plurality of fibers are generated by:
- dissolving a powder comprising a recombinant spider silk polypeptide into a solvent to generate a spin dope;
- extruding the spin dope into a coagulation bath to form a plurality of precursor fibers;
- and
- subjecting the plurality of precursor fibers to a turbulent air source, thereby generating the plurality of fibers comprising recombinant spider silk polypeptide,
- wherein one or more of the plurality of fibers has a mean coefficient of friction that is greater than 0.60.
A recombinant fiber comprising a recombinant polypeptide, wherein said fiber comprises a mean coefficient of friction of greater than 0.60.
A knitted garment comprising a staple yarn, wherein said staple yarn comprises wool and a plurality of recombinant fibers divided into discrete lengths, wherein said plurality of recombinant fibers comprise silk-like polypeptides, and wherein said plurality of recombinant fibers comprises a mean coefficient of friction of greater than 0.60.
A method of generating a fiber comprising recombinant spider silk polypeptide, comprising:
- dissolving a powder comprising a recombinant spider silk polypeptide into a solvent to generate a spin dope;
- extruding the spin dope into a coagulation bath to form a precursor fiber;
- and
- subjecting the precursor fiber to a turbulent air source, thereby generating the fiber comprising recombinant spider silk polypeptide,
- wherein the fiber comprising recombinant spider silk polypeptide has a mean coefficient of friction that is greater than 0.60.
Dependencies are inferred from the claim text.