# US 2019/0169133 A1 · Method for manufacturing nitrogen-containing heterocyclic compound and intermediate of same

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- Number: US 2019/0169133 A1
- Document ID: US20190169133A1
- Status: Published application
- Kind: A1
- Application number: 16/272,263
- Filed: 2019-02-11
- Published: 2019-06-06
- Earliest claimed: 2015-07-15
- Assignees: FUJIFILM Corporation
- Applicants: FUJIFILM Corporation
- Inventors: Yusuke NAGATO; Shinsuke MIZUMOTO; Tatsuya MURAKAMI; Tomoyuki TANAKA
- Web page: https://patentgrep.com/patent/US20190169133A1

## CPC

- C07D 239/48: Two nitrogen atoms
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- Y02P 20/55: Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

An object of the present invention is to provide a method for industrially manufacturing a nitrogen-containing heterocyclic compound which shows excellent FLT3 inhibitory activity and is useful as a pharmaceutical active ingredient of pharmaceutical products. The present invention provides a manufacturing method of a compound represented by General Formula [14] or a salt thereof (in the formula, R1 represents a C1-6 alkyl group which may be substituted; and R8 represents a leaving group or the like).

## Claims

### Claim 1

A compound represented by General Formula [14] or a salt thereof:
wherein in General Formula [14], R1 represents a C1-6 alkyl group which may be substituted; and R8 represents a chlorine atom, a hexamethylenetetraminium group, or a group represented by General Formula [4a]:
wherein in General Formula [4a], R2a represents a C1-6 alkoxycarbonyl group; R3a represents a C1-6 alkoxycarbonyl group; and * represents a binding position.

### Claim 2 (depends on 1)

The compound according to claim 1 or a salt thereof,
wherein R1 is a C2-4 alkyl group, and
R8 is a chlorine atom.

### Claim 3 (depends on 1)

The compound according to claim 1 or a salt thereof,
wherein R1 is a C2-4 alkyl group; and
R8 is a group represented by General Formula [4a]:
wherein in General Formula [4a], R2a represents a C1-6 alkoxycarbonyl group; R3a represents a C1-6 alkoxycarbonyl group; and * represents a binding position.