Multiple-component solid phases containing at least one active pharmaceutical ingredient
AssigneesUniversity of South Florida, The Regents of the University of Michigan
InventorsMichael J. Zaworotko, Nair Rodriguez-Hornedo, Brian Moulton
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Abstract
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.
Claims15
1-36. (canceled)
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a co-crystal comprising supramolecular synthons, each supramolecular synthon formed from stoichiometric amounts of at least one active pharmaceutical ingredient (API) and at least one co-crystal former,
- wherein the API has a first chemical functionality that permits formation of API homosynthons through non-covalent hydrogen bonding when the API is in its pure form,
- wherein the co-crystal former has a second chemical functionality complimentary to the first chemical functionality via non-covalent hydrogen bonding,
- wherein supramolecular synthons comprise non-covalent hydrogen bonding between the first chemical functionality of the API and the second chemical functionality of the co-crystal former.
Dependencies are inferred from the claim text.