# US 2019/0168177 A1 · Combination stirrer

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- Number: US 2019/0168177 A1
- Document ID: US20190168177A1
- Status: Published application
- Kind: A1
- Application number: 16/103,341
- Filed: 2018-08-14
- Published: 2019-06-06
- Earliest claimed: 2009-06-05
- Assignees: Hoffmann-La Roche Inc.
- Applicants: Hoffmann-La Roche Inc.
- Inventors: Marco JENZSCH; Max LECHNER; Michael POHLSCHEIDT; Christoph REESE; Alexander SCHOLZ; Hermann TEBBE
- Web page: https://patentgrep.com/patent/US20190168177A1

## CPC

- B01F 27/192: with dissimilar elements
- B01F 27/112: with arms, paddles, vanes or blades
- B01F 27/1122: anchor-shaped
- B01F 27/113: Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
- C12M 27/02: {Stirrer or mobile mixing elements}
- B01F: MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING (mixing paints B44D3/06)
- C12M: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; {APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS}

## Abstract

The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter di of the radially-conveying element. In one embodiment the stirrer according to the invention is a combination of one anchor stirrer with at least one inclined-blade stirrer. Furthermore the use of the stirrer according to the invention for the culture of cells in a dialysis method is described.

## Claims

### Claim 1

Agitator, comprising:
one radially-conveying element comprising at least two stirrer blades, and
one or more axially-conveying elements each comprising at least two stirrer blades,
wherein the stirrer blades of the radially-conveying element are parallel to each other,
wherein the outer diameter of all axially-conveying elements is equal to or less than the inner diameter of the radially-conveying element,
wherein all axially-conveying elements are individually connected to the radially-conveying element,
wherein all axially-conveying elements are located within the radially-conveying element, and
wherein all conveying elements have a fixed spatial orientation relative to each other.

### Claim 2 (depends on 1)

Agitator according to claim 1, characterized in that the number of axially-conveying elements is 1 or 2 or 3.

### Claim 3 (depends on 1)

Agitator according to claim 1, characterized in that one axially-conveying element is located at a maximum distance of 80% from the top of the blades of the radially-conveying element and/or one axially-conveying element is located at a maximum distance of 20% from the top of the blades of the radially-conveying element.

### Claim 4 (depends on 1)

Agitator according to claim 1, characterized in that opposing stirrer blades of the radially-conveying element are linked to each other by two opposite stirrer blades of an axially-conveying element.

### Claim 5 (depends on 1)

Agitator according to claim 1, characterized in that the radially-conveying element is an anchor impeller.

### Claim 6 (depends on 1)

Agitator according to claim 1, characterized in that the axially-conveying element is an inclined-blade stirrer.

### Claim 7 (depends on 6)

Agitator according to claim 6, characterized in that the pitch of the stirrer blades of the inclined-blade stirrer is between 10° and 80° relative to the shaft axis of the agitator.

### Claim 8 (depends on 1)

Agitator according to claim 1, characterized in that the radially-conveying element has 1 to 8 stirrer blades.

### Claim 9 (depends on 1)

Agitator according to claim 1, characterized in that the one or more axially-conveying elements have independent of each other 1 to 10 stirrer blades.

### Claim 10 (depends on 1)

Agitator according to claim 1, characterized in that the radially-conveying element has a height of at least 200 mm.

### Claim at position 11

11-22. (canceled)