# US 2019/0168162 A1 · Filtration assembly and filtration system including the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0168162 A1 - Document ID: US20190168162A1 - Status: Published application - Kind: A1 - Application number: 16/200,114 - Filed: 2018-11-26 - Published: 2019-06-06 - Earliest claimed: 2017-12-01 - Applicants: Corning Incorporated - Inventors: Ivan Nikolaevich Ivukin; Nikolaos Pantelis Kladias - Web page: https://patentgrep.com/patent/US20190168162A1 ## CPC - B01D 61/18: Apparatus therefor - B01D 61/20: Accessories; Auxiliary operations - B01D 63/087: {Single membrane modules} - B01D 2201/32: Flow characteristics of the filter - B01D 2313/08: Flow guidance means within the module or the apparatus - B01D 2313/086: Meandering flow path over the membrane - B01D 2315/10: Cross-flow filtration - B01D 2325/0283: Pore size - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) ## Abstract A tangential flow filtration assembly is provided herein. The tangential flow filtration assembly includes a first and second winding tangential flow channel having an inlet at an endpoint the respective tangential flow channel and an outlet at an opposite endpoint of the respective tangential flow channel, the tangential flow channels further having a first cross-sectional area at the inlet and a second cross-sectional area at the outlet. The tangential flow filtration assembly further includes a filtration membrane positioned between the first and second tangential flow channels. The first cross-sectional area of the first tangential flow channel is greater than the second cross-sectional area of the first tangential flow channel, and the first cross-sectional area of the second tangential flow channel is less than the second cross-sectional area of the second tangential flow channel. ## Claims ### Claim 1 A tangential flow filtration assembly comprising: a first winding tangential flow channel comprising an inlet at an endpoint of the first tangential flow channel and an outlet at an opposite endpoint of the first tangential flow channel, the first winding tangential flow channel further comprising a first cross-sectional area at the inlet and a second cross-sectional area at the outlet; a second winding tangential flow channel comprising an inlet at an endpoint of the second tangential flow channel and an outlet at an opposite endpoint of the second tangential flow channel the second winding tangential flow channel fluffier comprising a first cross-sectional area at the inlet and a second cross-sectional area at the outlet; and a filtration membrane positioned between the first and second tangential flow channels, wherein the first cross-sectional area of the first tangential flow channel is greater than the second cross-sectional area of the first tangential flow channel, and wherein the first cross-sectional area of the second tangential flow channels is less than the second cross-sectional area of the second tangential flow channel. ### Claim 2 (depends on 1) The tangential flow filtration assembly of claim 1, wherein transmembrane velocity is substantially constant along the length of the first and second tangential flow channels. ### Claim 3 (depends on 1) The tangential flow filtration assembly of claim 1, wherein transmembrane pressure is substantially constant along the length of the first and second tangential flow channels. ### Claim 4 (depends on 1) The tangential flow filtration assembly of claim 1, wherein the filtration membrane comprises a porous material. ### Claim 5 (depends on 1) The tangential flow filtration assembly of claim 1, wherein the filtration membrane comprises a first surface and a second surface, and wherein fluid in the first tangential flow channel flows tangentially over the first surface of the filtration membrane and fluid in the second tangential flow channel flows tangentially over the second surface of the filtration membrane. ### Claim 6 (depends on 1) The tangential flow filtration assembly of claim 1, wherein the filtration membrane comprises two filtration sheets arranged on either side of a porous material. ### Claim 7 (depends on 1) The tangential flow filtration assembly of claim 1, wherein when a transmembrane pressure is applied across the filtration membrane, a species of interest passes from a fluid in the first tangential flow channel through the filtration membrane and into a fluid in the second tangential flow channel. ### Claim 8 (depends on 7) The tangential flow filtration assembly of claim 7, wherein the filtration membrane comprises a porous material, and wherein the species of interest is smaller than the pores of the filtration membrane. ### Claim 9 (depends on 1) The tangential flow filtration assembly of claim 1, wherein when a transmembrane pressure is applied across the filtration membrane, species other than a species of interest pass from a fluid in the first tangential flow channel through the filtration membrane and into a fluid in the second tangential flow channel. ### Claim 10 (depends on 9) The tangential flow filtration assembly of claim 9, wherein the filtration membrane comprises a porous material, and wherein the species of interest is larger than the pores of the filtration membrane. ### Claim 11 A tangential flow filtration system comprising: a plurality of tangential flow filtration assemblies; and at least one conduit fluidly connecting one of the plurality of tangential flow filtration assemblies to a subsequent assembly of the plurality of tangential flow filtration assemblies, the system comprising n-1 conduits, wherein n is the number of tangential low filtration assemblies in the plurality of tangential flow filtration assemblies, and wherein each tangential flow filtration assembly comprises: a first winding tangential flow channel comprising an inlet at an endpoint of the first tangential flow channel and an outlet at an opposite endpoint of the first tangential flow channel, the first winding tangential flow channel further comprising a first cross-sectional area at the inlet and a second cross-sectional area at the outlet; a second winding tangential flow channel comprising an inlet at an endpoint of the second tangential flow channel and an outlet at an opposite endpoint of the second tangential flow channel the second winding tangential flow channel further comprising a first cross-sectional area at the inlet and a second cross-sectional area at the outlet; and a filtration membrane positioned between the first and second tangential flow channels, wherein the first cross-sectional area of the first tangential flow channel is greater than the second cross-sectional area of the first tangential flow channel, and wherein the first cross-sectional area of the second tangential flow channels is less than the second cross-sectional area of the second tangential flow channel. ### Claim 12 (depends on 11) The tangential flow filtration system of claim 11, wherein the at least one conduit fluidly connects an outlet of one of the plurality of tangential flow filtration assemblies to an inlet of a subsequent assembly of the plurality of tangential flow filtration assemblies. ### Claim 13 (depends on 11) The tangential flow filtration system of claim 11, wherein transmembrane velocity is substantially constant along the length of the first and second tangential flow channels of each of the plurality of tangential flow filtration assemblies. ### Claim 14 (depends on 11) The tangential flow filtration assembly of claim 11, wherein transmembrane pressure is substantially constant along the length of the first and second tangential flow channels of each of the plurality of tangential flow filtration assemblies. ### Claim 15 (depends on 11) The tangential flow filtration system of claim 11, wherein the filtration membrane of each of the plurality of tangential flow filtration assemblies comprises a porous material. ### Claim 16 (depends on 11) The tangential flow filtration system of claim 11, wherein the filtration membrane of each of the plurality of tangential flow filtration assemblies comprises a first surface and a second surface, and wherein fluid in the first tangential flow channel flows tangentially over the first surface of the filtration membrane and fluid in the second tangential flow channel flows tangentially over the second surface of the filtration membrane. ### Claim 17 (depends on 11) The tangential flow filtration system of claim 11, wherein the filtration membrane of each of the plurality of tangential flow filtration assemblies comprises two filtration sheets arranged on either side of a porous material. ### Claim 18 (depends on 11) The tangential flow filtration system of claim 11, wherein when a transmembrane pressure is applied across the filtration membrane of the plurality of tangential flow filtration assemblies, a species of interest passes from a fluid in the first tangential flow channel through the filtration membrane and into a fluid in the second tangential flow channel. ### Claim 19 (depends on 18) The tangential flow filtration system of claim 18, wherein the filtration membrane comprises a porous material, and wherein the species of interest is smaller than the pores of the filtration membrane. ### Claim 20 (depends on 11) The tangential flow filtration system of claim 11, wherein when a transmembrane pressure is applied across the filtration membrane of the plurality of tangential flow filtration assemblies, species other than a species of interest pass from a fluid in the first tangential flow channel through the filtration membrane and into a fluid in the second tangential flow channel. ### Claim 21 (depends on 20) The tangential flow filtration system of claim 20, wherein the filtration membrane comprises a porous material, and wherein the species of interest is larger than the pores of the filtration membrane. ### Claim 22 (depends on 11) The tangential flow filtration system of claim 11, wherein the filtration membrane of each of the plurality of tangential flow filtration assemblies comprises a porous material, and wherein the pore size of the filtration membrane of at least one of the plurality of tangential flow filtration assemblies is different than the pore size of the filtration membrane of a subsequent assembly of the plurality of tangential flow filtration assemblies. ### Claim 23 (depends on 22) The tangential flow filtration system of claim 22, wherein the pore size of the filtration membrane of at least one of the plurality of tangential flow filtration assemblies is larger than the pore size of the filtration membrane of a subsequent assembly of the plurality of tangential flow filtration assemblies.