# US 2019/0168030 A1 · System for skin cancer treatment using low intensity ultrasound

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- Number: US 2019/0168030 A1
- Document ID: US20190168030A1
- Status: Published application
- Kind: A1
- Application number: 16/206,142
- Filed: 2018-11-30
- Published: 2019-06-06
- Earliest claimed: 2013-11-22
- Assignees: Sonify Biosciences, LLC
- Applicants: Sonify Biosciences, LLC
- Inventors: Miriam Sara Boer; Daniel Jordan Rogers
- Web page: https://patentgrep.com/patent/US20190168030A1

## CPC

- A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092})
- A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules}
- A61B 8/0866: {involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby}
- A61B 8/0883: {for diagnosis of the heart}
- A61N 7/02: Localised ultrasound hyperthermia
- B33Y 10/00: Processes of additive manufacturing
- A61B 2017/00084: {Temperature}
- A61B 2018/00815: {measured by a thermistor}
- A61B 2018/00821: {measured by a thermocouple}
- A61N 2007/0034: {Skin treatment}
- A61N 2007/0082: {Scanning transducers}
- B33Y 80/00: Products made by additive manufacturing
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING

## Abstract

The present invention relates to a system for skin cancer treatment using low intensity ultrasound. The system comprises an ultrasound transducer, a temperature sensing unit, and a control unit. The temperature sensing unit measures the temperature of the skin being exposed to ultrasound and provides temperature data to the control unit, which controls the ultrasound transducer accordingly.

## Claims

### Claim 1

A method of treating skin cancer in a subject comprising
(a) scanning a contour of skin containing the skin cancer and generating data of the contour of the skin containing the skin cancer;
(b) using the generated data to fabricate a skin contacting surface of an ultrasound transducer having a contour the conforms to the contour of the skin containing the skin cancer;
(c) positioning the skin-contacting surface of the ultrasound transducer of the system onto the surface of the skin containing the cancer; and
(d) exposing the skin containing the cancer to low intensity ultrasound whereby the frequency, intensity and duration of the ultrasound are selected and controlled to induce a higher death rate of the skin cancer cells than normal skin cells in the focal zone.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the skin cancer comprises basal cell carcinoma, squamous cell carcinoma, melanoma, or any combination thereof.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the skin cancer comprises melanoma.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the subject is a mammal.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the mammal is a human.

### Claim 6 (depends on 1)

The method according to claim 1 wherein the skin contacting surface of the ultrasound transducer is produced by 3 dimensional (“3D”) laser scanning of the surface of the skin containing the cancer.

### Claim 7 (depends on 1)

The method according to claim 1 wherein the skin contacting surface is fabricated by molding.

### Claim 8 (depends on 1)

The method according to claim 1 wherein the skin contacting surface is fabricated by machining, including at least one of mechanical cutting, LASER cutting, and etching.

### Claim 9 (depends on 1)

The method according to claim 1 wherein the skin contacting surface is fabricated by an additive fabrication technology including at least one of 3 dimensional printing and stereolithography.

### Claim 10 (depends on 1)

The method according to claim 1 wherein the skin contacting surface is fabricated by at least one of extruding and etching.

### Claim 11

A method of treating skin cancer in a subject comprising
(a) scanning a contour of skin containing the skin cancer and generating data of the contour of the skin containing the skin cancer;
(b) using the generated data to select a skin contacting surface of an ultrasound transducer having a contour the conforms to the contour of the skin containing the skin cancer;
(c) positioning the skin-contacting surface of the ultrasound transducer of the system onto the surface of the skin containing the cancer; and
(d) exposing the skin containing the cancer to low intensity ultrasound whereby the frequency, intensity and duration of the ultrasound are selected and controlled to induce a higher death rate of the skin cancer cells than normal skin cells in the focal zone.