# US 2019/0167916 A1 · Applicator for cryoanesthesia and analgesia

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2019/0167916 A1
- Document ID: US20190167916A1
- Status: Published application
- Kind: A1
- Application number: 16/273,252
- Filed: 2019-02-12
- Published: 2019-06-06
- Earliest claimed: 2015-03-26
- Assignees: The Regents of the University of Michigan
- Applicants: The Regents of The University of Michigan
- Inventors: Cagri Giray BESIRLI; Stephen SMITH; Kevin P. PIPE; Gun-Ho KIM
- Web page: https://patentgrep.com/patent/US20190167916A1

## CPC

- A61M 5/422: {Desensitising skin}
- A61F 7/00: Heating or cooling appliances for medical or therapeutic treatment of the human body (hyperthermia using electric or magnetic fields or ultrasound A61N)
- A61F 7/007: {characterised by electric heating}
- A61M 5/315: Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod {or piston}; Appliances on the rod for facilitating dosing {; Dosing mechanisms}
- A61M 5/322: {Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston (devices for protecting guide needles in combination with catheters A61M25/0612)}
- A61F 9/0008: {Introducing ophthalmic products into the ocular cavity or retaining products therein (putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00)}
- A61F 2007/0004: {Eyes or part of the face surrounding the eyes}
- A61F 2007/0052: {for treatment of skin or hair}
- A61F 2007/0075: {using a Peltier element, e.g. near the spot to be heated or cooled}
- A61F 2007/0078: {with a battery}
- A61F 2007/0086: {with a thermostat}
- A61F 2007/0087: {Hand-held applicators}
- A61F 2007/0095: {with a temperature indicator}
- A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence)
- A61M 5/206: {with automatic needle insertion}
- A61M 2202/048: Anaesthetics
- A61M 2210/0612: Eyes
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

## Claims

### Claim 1

A device for cooling a target area of a cutaneous membrane, a mucous membrane, or tissue of a mucocutaneous zone, the device comprising:
an elongated body having a gripping portion to facilitate handheld manipulation by a user, the elongated body having a proximal end and a distal end;
a cooling system configured to cool the target area to a temperature ranging between 0° C. and −80° C. to induce anesthesia or analgesia in the target area; and
a controller for controlling the cooling system.

### Claim 2 (depends on 1)

The device according to claim 1, wherein the cooling system is configured to cool the target area to a temperature ranging from about −2° C. to about −50° C.

### Claim 3 (depends on 1)

The device according to claim 1, wherein the cooling system comprises a liquid.

### Claim 4 (depends on 1)

The device according to claim 1, wherein the cooling system comprises a low temperature substance.

### Claim 5 (depends on 1)

The device according to claim 1, wherein the cooling system comprises a thermoelectric component.

### Claim 6 (depends on 1)

The device according to claim 1, wherein the cooling system comprises an endothermic reaction cooling system.

### Claim 7 (depends on 1)

The device according to claim 1, wherein the cooling system comprises a compression cooling system.

### Claim 8 (depends on 1)

The device according to claim 1, wherein the cooling system comprises a temperature sensor and feedback loops to maintain tightly regulated temperature.

### Claim 9 (depends on 1)

The device according to claim 1, wherein the device does not include a needle.

### Claim 10 (depends on 1)

The device according to claim 1, wherein the target area is an ocular target area.

### Claim 11 (depends on 1)

The device according to claim 1, wherein the target area is a cutaneous or mucocutaneous target area.