# US 2019/0167847 A1 · Magnetically actuated articular cartilage regeneration system

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- Number: US 2019/0167847 A1
- Document ID: US20190167847A1
- Status: Published application
- Kind: A1
- Application number: 16/097,714
- Filed: 2017-10-26
- Published: 2019-06-06
- Earliest claimed: 2016-10-26
- Assignees: Industry Foundation of Chonnam National University
- Applicants: Industry Foundation of Chonnam National University
- Inventors: Suk Ho PARK; Jongoh PARK; Ji Won HAN; Byung Jeon KANG; Gwangjun GO
- Web page: https://patentgrep.com/patent/US20190167847A1

## CPC

- A61L 27/3817: {Cartilage-forming cells, e.g. pre-chondrocytes}
- A61B 6/12: Arrangements for detecting or locating foreign bodies
- A61B 6/50: specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B 6/505: {for diagnosis of bone}
- A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data}
- A61F 2/30: Joints
- A61F 2/30756: {Cartilage endoprostheses (A61F2/3603 takes precedence)}
- A61K 35/28: Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A61K 35/32: Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
- A61K 41/00: Medicinal preparations obtained by treating materials with wave energy or particle radiation {; Therapies using these preparations}
- A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb}
- A61K 47/6929: {the form being a nanoparticle, e.g. an immuno-nanoparticle}
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/3834: {Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells}
- A61L 27/3852: {Cartilage, e.g. meniscus}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61N 2/002: {in combination with another treatment}
- A61N 2/004: {specially adapted for a specific therapy}
- A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence)
- A61N 2/06: using magnetic fields produced by permanent magnets (A61N2/12 takes precedence)
- G16H 50/30: for calculating health indices; for individual health risk assessment
- A61F 2002/30766: {Scaffolds for cartilage ingrowth and regeneration}
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2430/06: for cartilage reconstruction, e.g. meniscus
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The present invention provides a magnetically-actuated articular cartilage regeneration system for efficiently and nonsurgically regenerating articular cartilage.

## Claims

### Claim 1

A composition for regenerating cartilage comprising a microstructure to which at least one magnetic substance and at least one cartilage-producing cell are attached.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the cartilage-producing cell is a cartilage cell or stem cell.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the stem cell is a bone marrow-derived stem cell or fat-derived stem cell.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the magnetic substance is a magnetic nanoparticle.

### Claim 5 (depends on 4)

The composition of claim 4, wherein the magnetic nanoparticle is an amine-functionalized Fe3O4 nanoparticle.

### Claim 6 (depends on 5)

The composition of claim 5, wherein the amine-functionalized Fe3O4 nanoparticle is covalently linked to a carboxyl group of the microstructure.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the microstructure is a biocompatible polymer scaffold.

### Claim 8 (depends on 7)

The composition of claim 7, wherein the biocompatible polymer scaffold is a porous scaffold.

### Claim 9 (depends on 7)

The composition of claim 7, wherein the biocompatible polymer scaffold is prepared by polylactic-glycolic acid (PLGA), polylactic acid (PLA), polyglycolic acid (PGA), polyvinyl alcohol (PVA), polyethylene glycol (PEG), poly(N-2-hydroxypropyl methacrylamide), polyhydroxyalkanoic acid(PHA), polycaprolactone (PCL), poly(propylene fumarate), polyanhydride, polyacetal, or polycarbonate, poly(ortho ester).

### Claim 10 (depends on 1)

A magnetically-actuated articular cartilage regeneration system, comprising:
a composition for regenerating cartilage of claim 1;
an image-photographing unit for imaging the composition for regenerating cartilage and a lesion after irradiating x-ray on a defected area of cartilage; and
a magnetic field forming unit for transporting the composition for regenerating cartilage to the defected area of cartilage.

### Claim 11 (depends on 10)

The magnetically-actuated articular cartilage regeneration system of claim 10, wherein the magnetic field forming unit is a coil type or a wearable type.

### Claim 12 (depends on 10)

The magnetically-actuated articular cartilage regeneration system of claim 10, wherein the formation of magnetic field in the magnetic field forming unit is by electromagnet or permanent magnet.

### Claim 13 (depends on 12)

The magnetically-actuated articular cartilage regeneration system of claim 12, wherein the permanent magnet is ferrite, neodymium, alnico, samarium cobalt, or rubber magnet.