Ready-to-use, hydrophilic, self-dispersive, fragmentable and biodegradable porous sponge matrix and a method of manufacturing thereof

A porous sponge matrix, comprising:

• a biocompatible and biodegradable polymer scaffold comprising a blend of synthetic and natural polymers as a three-dimensional scaffold polyelectrolyte complex (PEC) having vesicular micro-voids and an inner surface area larger than its outer surface area;
• and
• at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells impregnated within the vesicular micro-voids of the three-dimensional scaffold PEC, wherein the three-dimensional scaffold PEC comprises a lyophilized and homogenized polymer formed from a sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution comprising polyvinyl chloride at about 5% to 15%, Gelatin at about 2% to 7% and Sodium Alginate at about 0.5% to 2%.

A porous sponge matrix, comprising:

• a biocompatible and biodegradable polymer scaffold comprising a blend of synthetic and natural polymers as a three-dimensional scaffold polyelectrolyte complex (PEC) having vesicular micro-voids and an inner surface area larger than its outer surface area;
• and
• at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells impregnated within the vesicular micro-voids of the three-dimensional scaffold PEC, wherein the three-dimensional scaffold PEC comprises a lyophilized and homogenized polymer formed from a sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution comprising polyvinyl alcohol at about 7.5%, Gelatin at about 10%, Sodium Alginate at 1%, and polyethylene glycol-200 at about 3 ml.