# US 2019/0167835 A1 · Antioxidant and antimicrobial wound dressing materials

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- Number: US 2019/0167835 A1
- Document ID: US20190167835A1
- Status: Published application
- Kind: A1
- Application number: 16/206,931
- Filed: 2018-11-30
- Published: 2019-06-06
- Earliest claimed: 2003-11-18
- Assignees: KCI USA, Inc.
- Applicants: KCI USA, Inc.
- Inventors: Deborah ADDISON; David GREENHALGH; Breda Mary CULLEN
- Web page: https://patentgrep.com/patent/US20190167835A1

## CPC

- A61L 15/44: Medicaments
- A61F 13/0203: with fluid retention members
- A61F 13/0206: with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
- A61F 13/0209: {comprising superabsorbent material}
- A61F 13/0213: {the fluid retention member being a layer of hydrocolloid, gel forming material}
- A61F 13/0226: {characterised by the support layer}
- A61F 13/0256: {characterized by the parametric properties of the adhesive}
- A61L 15/20: containing organic materials
- A61L 15/28: Polysaccharides or their derivatives {(A61L15/225 takes precedence)}
- A61L 15/325: {Collagen}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 15/56: Wetness-indicators or colourants
- A61L 15/64: specially adapted to be resorbable inside the body
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- B65B 5/04: Packaging single articles
- B65B 55/12: Sterilising contents prior to, or during, packaging
- A61L 2300/21: Acids
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B65B: MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING (bundling and pressing devices for cigars A24C1/44; devices for tensioning and securing binders adapted to be supported by the article or articles to be bound B25B25/00; applying closure members to bottles, jars or similar containers B67B1/00-B67B6/00; concurrent cleaning, filling and closing of bottles B67C7/00; emptying bottles, jars, cans, casks, barrels or similar containers B67C9/00)

## Abstract

A wound dressing material may include a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may include collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may, for example, be an aniline or acridine dye. Also disclosed are methods of making such materials, and wound dressings that include such materials.

## Claims

### Claim 1

A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt.

### Claim 2 (depends on 1)

A wound dressing material according to claim 1, wherein the substrate comprises a solid bioabsorbable material, preferably selected from the group consisting of collagens, oxidized celluloses, chitosans, galactomannans, glycosaminoglycans, and mixtures thereof.

### Claim 3 (depends on 2)

A wound dressing material according to claim 2, wherein the substrate comprises a solid bioabsorbable material selected from the group consisting of collagens, oxidized celluloses, chitosans, and mixtures thereof.

### Claim 4 (depends on 1)

A wound dressing material according to claim 1, wherein the substrate is selected from the group consisting of celluloses, alginates, polyacrylates, polyurethanes, polyamides, and mixtures thereof.

### Claim 5 (depends on 1)

A wound dressing material according to claim 1, wherein the wound dressing material is in the form of a continuous solid sheet, an apertured solid sheet, a web, a woven fabric, a knitted fabric, a nonwoven fabric, a freeze-dried sponge or a solvent-dried sponge.

### Claim 6 (depends on 1)

A wound dressing material according to claim 1, wherein the polymeric substrate comprises an anionic polymer, and said silver salt comprises a salt of Ag+ with the anionic polymer.

### Claim 7 (depends on 1)

A wound dressing material according to claim 1, wherein the composition comprises from about 0.01 wt. % to about 5 wt. % of silver, based on the dry weight of the composition.

### Claim 8 (depends on 1)

A wound dressing material according to claim 1, wherein the dyestuff comprises an antioxidant dyestuff, for example selected from the group consisting of aniline dyes, acridine dyes, thionine dyes, bis-naphthalene dyes, thiazine dyes, azo dyes, anthraquinones, and mixtures thereof.

### Claim 9 (depends on 8)

A wound dressing material according to claim 8, wherein the antioxidant dyestuff is selected from the group consisting of gentian violet, aniline blue, methylene blue, crystal violet, acriflavine, 9-aminoacridine, acridine yellow, acridine orange, proflavin, quinacrine, brilliant green, trypan blue, trypan red, malachite green, azacrine, methyl violet, methyl orange, methyl yellow, ethyl violet, acid orange, acid yellow, acid blue, acid red, thioflavin, alphazurine, indigo blue, methylene green, and mixtures thereof.

### Claim 10 (depends on 1)

A wound dressing material according to claim 1, wherein the dyestuff is present in an amount of from about 0.2 to about 2 wt. % based on the dry weight of the material.

### Claim 11 (depends on 1)

A wound dressing material according to claim 1, wherein the polymeric substrate consists essentially of a mixture of an oxidized cellulose with a collagen and/or a chitosan.

### Claim 12 (depends on 1)

A wound dressing material according to claim 1, wherein the material is sterile and packaged in a microorganism-impermeable container.

### Claim 13 (depends on 1)

A wound dressing material according to claim 1, wherein the material has a free radical activity in the diphenylpicrylhydrazyl (DPPH) test for antioxidant activity as herein defined of at least about 15%.

### Claim 14 (depends on 1)

A method for treating a wound, the method comprising administering to the wound a wound dressing material of claim 1.

### Claim 15 (depends on 14)

The method of claim 14, wherein the wound is a chronic wound, preferably selected from the group consisting of ulcers of venous ulcers, decubitus ulcers, or diabetic ulcers.

### Claim at position 16

16-19. (canceled)