# US 2019/0167823 A1 · Method for treating solution contaminated with porcine circoviruses > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167823 A1 - Document ID: US20190167823A1 - Status: Published application - Kind: A1 - Application number: 16/323,996 - Filed: 2017-08-08 - Published: 2019-06-06 - Earliest claimed: 2016-08-09 - Assignees: Asahi Kasei Medical Co., Ltd. - Applicants: Asahi Kasei Medical Co., Ltd. - Inventors: Mikihiro YUNOKI; Takeru URAYAMA; Kaoru SAKAI; Tomoyuki MIYABAYASHI - Web page: https://patentgrep.com/patent/US20190167823A1 ## CPC - A61L 2/022: Filtration - C07K 1/34: by filtration, ultrafiltration or reverse osmosis - C12N 7/00: Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) - A61L 2103/05: Living organisms or biological materials - C07K 16/00: Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies - C07K 16/081: DNA viruses - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) ## Abstract The present invention provides a method for treating a solution contaminated with porcine circovirus, comprising the steps of: adjusting a pH of a solution contaminated with porcine circovirus to range from 3.0 to 7.0; and treating the pH-adjusted solution with a filtration membrane having an LRV for bacteriophage PP7 of 4 or more. ## Claims ### Claim 1 A method for treating a solution contaminated with porcine circovirus, comprising: adjusting a pH of a solution contaminated with porcine circovirus to range from 3.0 to 7.0; and treating the pH-adjusted solution with a filtration membrane having an LRV for bacteriophage PP7 of 4 or more. ### Claim 2 (depends on 1) The method for treating a solution contaminated with porcine circovirus according to claim 1, wherein the pH-adjusted solution contains not more than 0.50 M glycine. ### Claim 3 (depends on 2) The method for treating a solution contaminated with porcine circovirus according to claim 2, wherein the solution contains 0.010 to 0.40 M glycine. ### Claim 4 (depends on 2) The method for treating a solution contaminated with porcine circovirus according to claim 2, wherein the solution contains 0.20 to 0.35 M glycine. ### Claim 5 (depends on 1) The method for treating a solution contaminated with porcine circovirus according to claim 1, wherein the solution contaminated with porcine circovirus contains not more than 5.0 w/v % of a protein. ### Claim 6 (depends on 5) The method for treating a solution contaminated with porcine circovirus according to claim 5, wherein when the protein concentration in the solution contaminated with porcine circovirus is less than 0.10 w/v %, the pH of the solution contaminated with porcine circovirus is adjusted to range from 3.0 to 6.0. ### Claim 7 (depends on 5) The method for treating a solution contaminated with porcine circovirus according to claim 5, wherein when the protein concentration of the solution contaminated with porcine circovirus ranges from 0.10 to 1.5 w/v %, the pH of the solution contaminated with porcine circovirus is adjusted to range from 3.8 to 7.0. ### Claim 8 (depends on 5) The method for treating a solution contaminated with porcine circovirus according to claim 5, wherein the protein is IgG. ### Claim 9 (depends on 1) The method for treating a solution contaminated with porcine circovirus according to claim 1, wherein the pH-adjusted solution is treated at 50 to 100 L/m2. ### Claim 10 (depends on 1) The method for treating a solution contaminated with porcine circovirus according to claim 1, wherein the LRV for porcine circovirus is 2 or more. ### Claim 11 A method for treating a solution, comprising: adjusting a pH of a solution to be treated to range from 3.0 to 7.0; and treating the pH-adjusted solution with a filtration membrane having an LRV for bacteriophage PP7 of 4 or more. ### Claim 12 (depends on 2) The method for treating a solution contaminated with porcine circovirus according to claim 2, wherein the solution contaminated with porcine circovirus contains not more than 5.0 w/v % of a protein. ### Claim 13 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein the solution contains 0.010 to 0.40 M glycine. ### Claim 14 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein the solution contains 0.20 to 0.35 M glycine. ### Claim 15 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein when the protein concentration in the solution contaminated with porcine circovirus is less than 0.10 w/v %, the pH of the solution contaminated with porcine circovirus is adjusted to range from 3.0 to 6.0. ### Claim 16 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein when the protein concentration of the solution contaminated with porcine circovirus ranges from 0.10 to 1.5 w/v %, the pH of the solution contaminated with porcine circovirus is adjusted to range from 3.8 to 7.0. ### Claim 17 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein the protein is IgG. ### Claim 18 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein the pH-adjusted solution is treated at 50 to 100 L/m2. ### Claim 19 (depends on 12) The method for treating a solution contaminated with porcine circovirus according to claim 12, wherein the LRV for porcine circovirus is 2 or more.