# US 2019/0167765 A1 · Human serum albumin-based topical ointment for treatment of acne, psoriasis, egfr-induced toxicity, premature skin aging and other skin conditions

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- Number: US 2019/0167765 A1
- Document ID: US20190167765A1
- Status: Published application
- Kind: A1
- Application number: 16/259,559
- Filed: 2019-01-28
- Published: 2019-06-06
- Earliest claimed: 2009-04-24
- Assignees: Albumin Therapeutics
- Applicants: Albumin Therapeutics
- Inventors: Daniel C. CARTER
- Web page: https://patentgrep.com/patent/US20190167765A1

## CPC

- A61K 38/38: Albumins
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 38/385: {Serum albumin}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 17/10: Anti-acne agents
- A61P 27/02: Ophthalmic agents
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A method for treating psoriasis, eczema, acne and like skin conditions for sanitization, pharmaceutical compounding and protection of the skin from extreme environmental conditions is provided wherein serum albumin is applied in an amount effective to treat, reduce the symptoms and improve the appearance of affected skin due to psoriasis, eczema, and acne and like conditions, enhance the delivery performance or stability of pharmaceutical compounding bases, protect the skin from the environment and premature aging, and to lubricate and/or promote the healing of eye after surgical or accidental trauma, when combined with a suitable topical ointment, antibacterial or dermatological agent, pharmaceutical compounding ointment or bases, vehicle, carrier or excipient. The albumin may be used in a suitable form such as an alcohol-based gel.

## Claims

### Claim 1

A method of treating the skin comprising topically applying a composition comprising human serum albumin in an amount effective to treat a skin or scalp condition selected from the group consisting of psoriasis, eczema, acne, chapped lips, and EGRF inhibitor-related cutaneous skin toxicities, or to protect the skin from a condition selected from the group consisting of overexposure to the elements, environmental factors, metabolic, pharmaceutical or other pollutants and premature aging, and a pharmaceutically acceptable vehicle, carrier or excipient to the skin of a subject in need thereof.

### Claim 2 (depends on 1)

The method according to claim 1 wherein the environmental factors are selected from the group consisting of extreme cold, sun damage, and damage by UV or other radiation.

### Claim 3 (depends on 1)

The method of claim 1 wherein the composition comprises 1-90 mg/ml human serum albumin in a 1-90% alcohol solution.

### Claim 4 (depends on 1)

The method of claim 1 wherein the composition comprises 1 to 90 mg/ml recombinant human serum albumin in a 1 to 90% alcohol gel or solution.

### Claim 5 (depends on 5)

The method according to claim 5 wherein the serum albumin in the alcohol gel or solution is at a concentration in the range of about 1 to 250 mg/ml.

### Claim 6 (depends on 1)

The method according to claim 1 wherein the composition is used on skin wounds, bed sores or damaged skin in an amount effective to sanitize the wound surface.

### Claim 7 (depends on 1)

The method according to claim 1 wherein the composition is applied at a pH in the range of from 5.5 to 8.0.

### Claim 8 (depends on 1)

The method according to claim 1 wherein the human serum albumin is recombinant human serum albumin.

### Claim 9 (depends on 1)

The method according to claim 1 wherein the composition further comprises other UV or other radiation protective agents.

### Claim 10

A method of preparing the skin for surgical incision comprising topically administering serum albumin with an antimicrobial in a dermatological agent, vehicle, carrier or excipient in an amount affective to sanitize the targeted skin areas.

### Claim 11

A method of augmenting the natural albumin concentration of the skin barrier comprising topically applying a composition comprising human serum albumin in an amount effective for protecting targeted areas of the skin against a condition selected from the group consisting of overexposure to the elements, environmental factors, metabolic, pharmaceutical or other pollutants and premature aging, and a pharmaceutically acceptable vehicle, carrier or excipient to the skin of a subject in need thereof.

### Claim 12 (depends on 11)

The method according to claim 11 wherein the augmented albumin is used to promote the natural health and maintenance of the skin surface and barrier.

### Claim 13 (depends on 11)

The method of claim 11 wherein the composition comprises 1-90 mg/ml human serum albumin in a 1-90% alcohol solution.

### Claim 14 (depends on 11)

The method of claim 11 wherein the composition comprises 1 to 90 mg/ml recombinant human serum albumin in a 1 to 90% alcohol gel or solution.

### Claim 15 (depends on 14)

The method according to claim 14 wherein the serum albumin in the alcohol gel or solution is at a concentration in the range of about 1 to 250 mg/ml.