# US 2019/0167752 A1 · Drug or health care product preventing or treating liver and kidney damage-related diseases and use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2019/0167752 A1
- Document ID: US20190167752A1
- Status: Published application
- Kind: A1
- Application number: 15/526,870
- Filed: 2015-04-29
- Published: 2019-06-06
- Earliest claimed: 2014-11-15
- Assignees: Guangxi Hebabiz Pharmaceutical Technology Co.,Ltd.
- Applicants: Guangxi Hebabiz Pharmaceutical Technology Co., Ltd.
- Inventors: James Zhou
- Web page: https://patentgrep.com/patent/US20190167752A1

## CPC

- A61K 36/8969: Polygonatum (Solomon's seal)
- A61K 36/232: Angelica
- A61K 36/233: Bupleurum
- A61K 36/236: Ligusticum (licorice-root)
- A61K 36/287: Chrysanthemum, e.g. daisy
- A61K 36/482: Cassia, e.g. golden shower tree
- A61K 36/71: Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K 36/752: Citrus, e.g. lime, orange or lemon
- A61K 36/804: Rehmannia
- A61K 36/815: Lycium (desert-thorn)
- A61K 36/888: Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K 36/8968: Ophiopogon (Lilyturf)
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 13/12: of the kidneys
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A traditional Chinese medicine composition for protecting the liver and kidney and a preparation method and use thereof. The composition is composed of 100-200 parts of Polygonatum odoratum, 100-200 parts of fructus lycii, 80-160 parts of radix ophiopogonis, 70-130 parts of Angelica sinensis, 70-130 parts of semen cassiae, 70-130 parts of white peony root, 70-130 parts of dried orange peel, 70-130 parts of prepared rehmannia root, 70-130 parts of chrysanthemum, 30-70 parts of rhizome chuanxiong, 20-40 parts of Irkutsk anemone rhizome, and 10-20 parts of bupleurum by weight.

## Claims

### Claim 1

A traditional Chinese medicine composition for protecting the liver and kidney, which consists of following weight parts of crush drug:
100-200 parts of Polygonatum odoratum,
100-200 parts of fructus lycii,
80-160 parts of radix ophiopogonis,
70-130 parts of Angelica sinensis,
70-130 parts of semen cassiae,
70-130 parts of white peony root,
70-130 parts of dried orange peel,
70-130 parts of prepared rehmannia root,
70-130 parts of chrysanthemum,
30-70 parts of rhizome chuanxiong,
20-40 parts of Irkutsk anemone rhizome and
10-20 parts of bupleurum.

### Claim 2 (depends on 1)

The traditional Chinese medicine composition of claim 1 wherein the composition comprises:
the volatile oil of Angelica sinensis, rhizome chuanxiong, chrysanthemum, bupleurum, Irkutsk anemone rhizome and dried orange peel,
non-alcohol precipitation of water soluble matter of Angelica sinensis, rhizome chuanxiong, chrysanthemum, bupleurum, Irkutsk anemone rhizome and dried orange peel for extracting volatile oil, non-alcohol precipitation of water soluble matter of Angelica sinensis, rhizome chuanxiong, chrysanthemum, bupleurum, Irkutsk anemone rhizome and dried orange peel for extracting volatile oil and extracting water soluble matter, and
non-alcohol precipitation of water soluble matter of Polygonatum odoratum, fructus lycii, radix ophiopogonis, semen cassiae, white peony root and prepared rehmannia root.

### Claim 3 (depends on 2)

The traditional Chinese medicine composition of claim 2, wherein:
the volatile oil is prepared by adding water to the distillation and retaining the volatile oil;
the aqueous solution is prepared by water distillation and water retention;
the water extract is prepared by boiling water and
retention of water solution preparation;
the non-alcohol precipitation is prepared by increasing concentration of alcohol and retaining alcohol soluble substance, and
alcohol is ethanol.

### Claim 4 (depends on 1)

A preparation method of the traditional Chinese medicine composition of claim 1 comprising:
(1) smashing and mixing Angelica sinensis, rhizome chuanxiong, chrysanthemum and bupleurum, Irkutsk anemone rhizome and dried orange peel, adding water and performing distillation, retaining volatile oil, water solution and dregs which are not dissolved in water;
(2) mixing dregs obtained in step (1) and Polygonatum odoratum, fructus lycii, radix ophiopogonis, semen cassiae, white peony root and prepared rehmannia root, and decocting the mixture with water, then mixing the filtrate and aqueous solution, concentrate, increasing the alcohol concentration, recovering the supernatant after alcohol, filtered and concentrated, as a clear paste; and
(3) mixing the clear paste obtained from step (2) and the volatile oil obtained from step (1).

### Claim 5 (depends on 1)

A traditional Chinese medicine preparation for the protection of liver and kidney, comprising the traditional Chinese medicine composition of claim 1 and a pharmaceutically acceptable carrier.

### Claim 6 (depends on 5)

The preparation of claim 5, wherein the pharmaceutically acceptable carrier includes sugar, honey, ethyl p-hydroxybenzoate and mixtures thereof.

### Claim 7 (depends on 6)

The traditional Chinese medicine formulation of claim 6, which is prepared by a process comprising the following steps:
(1) smash and mix Angelica sinensis, rhizoma chuanxiong, chrysanthemum, bupleurum, Irkutsk anemone rhizome and dried orange peel, add water and perform distillation, retention of volatile oil, water solution and dregs not dissolve in water;
(2) mix dregs obtained in step (1) and Polygonatum odoratum, fructus lycii, radix ophiopogonis, semen cassiae, white peony root and prepared rehmannia root, and decoct them with water, then mix the filtrate and aqueous solution, concentrate, increase the alcohol concentration, the supernatant was recovered after alcohol, filtered and concentrated, clear paste; and,
(3) mix the clear paste obtained from step (2) and volatile oil obtained from step (1), and the carrier acceptable in pharmacy.

### Claim 8 (depends on 1)

Application of traditional Chinese medicine composition as described in claim 1 for preparing medicine for protecting liver and/or kidney.

### Claim 9 (depends on 9)

Application of claim 9 wherein the protection of liver and/or kidney is prevention or treatment of liver injury and/or renal injury.

### Claim 10 (depends on 1)

Application of the traditional Chinese medicine composition described in claim 1 in preparation of drugs for lowering level of cholesterol, triglyceride, low density lipoprotein, creatinine, urea nitrogen, and uric acid, drugs for improving level of high density lipoprotein, and/or drugs for reducing fatty liver symptoms.