# US 2019/0167748 A1 · Whitening agent

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- Number: US 2019/0167748 A1
- Document ID: US20190167748A1
- Status: Published application
- Kind: A1
- Application number: 16/306,281
- Filed: 2017-02-17
- Published: 2019-06-06
- Earliest claimed: 2016-02-24
- Assignees: Kao Corporation; Bogor Agricultural University
- Applicants: Kao Corporation; Bogor Agricultural University
- Inventors: Hiroshi HASHIMOTO; Mitsuyuki HOTTA; Maeko IWAMURA; Latifah Kasim DARUSMAN (Deceased); Irmanida BATUBARA; Edy DJAUHARI (Deceased); Rudi HERYANTO; Tohru MITSUNAGA
- Web page: https://patentgrep.com/patent/US20190167748A1

## CPC

- A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/35: Ketones, e.g. benzophenone
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 31/12: Ketones
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K 2800/782: Enzyme inhibitors; Enzyme antagonists
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provision of a material, which has tyrosinase-inhibiting activity and is effective for skin whitening. A tyrosinase inhibitor comprising Syzygium polyanthum or an extract therefrom as an active ingredient is provided. Also, a compound represented by any one of the following formulae (I) to (III) and a tyrosinase inhibitor comprising the compound as an active ingredient are provided.

## Claims

### Claim at position 1

1-12. (canceled)

### Claim 13

A method for inhibiting a tyrosinase in a subject, comprising administering to the subject an effective amount of Syzygium polyanthum or an extract therefrom.

### Claim 14

A method for inhibiting melanogenesis in a subject, comprising administering to the subject an effective amount of Syzygium polyanthum or an extract therefrom.

### Claim 15

A method for whitening skin in a subject, comprising administering to the subject an effective amount of Syzygium polyanthum or an extract therefrom.

### Claim 16

A compound represented by a formula selected from the group consisting of formulae (I), (II) and (III):

### Claim at position 6

17-28. (canceled)

### Claim 29 (depends on 16)

A method for inhibiting a tyrosinase in a subject in need thereof, comprising administering to the subject an effective amount of at least one compound according to claim 16.

### Claim 30 (depends on 16)

A method for inhibiting melanogenesis in a subject in need thereof, comprising administering to the subject an effective amount of at least one compound according to claim 16.

### Claim 31 (depends on 16)

A method for whitening skin in a subject in need thereof, comprising administering to the subject an effective amount of at least one compound according to claim 16.

### Claim at position 10

32-41. (canceled)