# US 2019/0167742 A1 · Therapy for promoting cell growth

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- Number: US 2019/0167742 A1
- Document ID: US20190167742A1
- Status: Published application
- Kind: A1
- Application number: 16/242,654
- Filed: 2019-01-08
- Published: 2019-06-06
- Earliest claimed: 2009-03-27
- Assignees: Moleac Pte. Ltd.
- Applicants: Moleac Pte. Ltd.
- Inventors: Michel Maurice Jacques Lazdunski; Catherine Louise Heurteaux; David Picard
- Web page: https://patentgrep.com/patent/US20190167742A1

## CPC

- A61K 36/232: Angelica
- A61K 35/62: Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
- A61K 36/236: Ligusticum (licorice-root)
- A61K 36/286: Carthamus (distaff thistle)
- A61K 36/481: Astragalus (milkvetch)
- A61K 36/537: Salvia (sage)
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61K 36/69: Polygalaceae (Milkwort family)
- A61K 36/736: Prunus, e.g. plum, cherry, peach, apricot or almond
- A61K 36/882: Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 21/02: Muscle relaxants, e.g. for tetanus or cramps
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/06: Antimigraine agents
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 25/14: for treating abnormal movements, e.g. chorea, dyskinesia
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

There is disclosed the use of a composition for promoting neuronal growth of neurons in tissues of the central or peripheral nervous system. There is also disclosed a method for inducing proliferation or differentiation of neuronal cells.

## Claims

### Claim at position 1

1-73. (canceled)

### Claim 74

A composition consisting of the following four herbal components:
i) Radix Polygalae;
ii) Radix Astragali;
iii) Rhizoma Chuanxiong; and
iv) Radix Angelicae sinensis,
wherein each herbal component is present in the composition as an unprocessed or crushed herb or as a purified extract.

### Claim 75 (depends on 74)

The composition according to claim 74, wherein each herbal component is present in the composition as a purified extract.

### Claim 76 (depends on 74)

The composition according to claim 74, wherein Radix Polygalae, Rhizoma Chuanxiong, Radix Angelicae sinensis, and Radix Astragali are present in the composition in a ratio of about 1:1:1:5 by weight, respectively.

### Claim 77 (depends on 75)

The composition according to claim 75, wherein Radix Polygalae, Rhizoma Chuanxiong, Radix Angelicae sinensis, and Radix Astragali are present in the composition in a ratio of about 1:1:1:5 by weight, respectively.

### Claim 78 (depends on 74)

The composition according to claim 74, wherein said composition is a pharmaceutical composition further comprising a pharmaceutically acceptable additive, carrier or diluent.

### Claim 79 (depends on 75)

The composition according to claim 75, wherein said composition is a pharmaceutical composition further comprising a pharmaceutically acceptable additive, carrier or diluent.

### Claim 80 (depends on 76)

The composition according to claim 76, wherein said composition is a pharmaceutical composition further comprising a pharmaceutically acceptable additive, carrier or diluent.

### Claim 81 (depends on 77)

The composition according to claim 77, wherein said composition is a pharmaceutical composition further comprising a pharmaceutically acceptable additive, carrier or diluent.

### Claim 82 (depends on 78)

The composition according to claim 78, formulated for oral delivery.

### Claim 83 (depends on 79)

The composition according to claim 79, formulated for oral delivery.

### Claim 84 (depends on 80)

The composition according to claim 80, formulated for oral delivery.

### Claim 85 (depends on 81)

The composition according to claim 81, formulated for oral delivery.

### Claim 86 (depends on 78)

The composition according to claim 78, formulated as one or more tablets or capsules.

### Claim 87 (depends on 79)

The composition according to claim 79, formulated as one or more tablets or capsules.

### Claim 88 (depends on 80)

The composition according to claim 80, formulated as one or more tablets or capsules.

### Claim 89 (depends on 81)

The composition according to claim 81, formulated as one or more tablets or capsules.

### Claim 90 (depends on 78)

The composition according to claim 78, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more supplemental agents.

### Claim 91 (depends on 79)

The composition according to claim 79, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more supplemental agents.

### Claim 92 (depends on 80)

The composition according to claim 80, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more supplemental agents.

### Claim 93 (depends on 81)

The composition according to claim 81, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more supplemental agents.

### Claim 94 (depends on 78)

The composition according to claim 78, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more vitamins, mineral supplements, herbal supplements, fish oils and/or Western medicines.

### Claim 95 (depends on 79)

The composition according to claim 79, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more vitamins, mineral supplements, herbal supplements, fish oils and/or Western medicines.

### Claim 96 (depends on 80)

The composition according to claim 80, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more vitamins, mineral supplements, herbal supplements, fish oils and/or Western medicines.

### Claim 97 (depends on 81)

The composition according to claim 81, administered to a subject to diminish the effects of a stroke and/or a neurodegenerative disorder, wherein said composition is administered in combination with one or more vitamins, mineral supplements, herbal supplements, fish oils and/or Western medicines.
