# US 2019/0167741 A1 · Medicament for the treatment and/or prevention of endometriosis

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- Number: US 2019/0167741 A1
- Document ID: US20190167741A1
- Status: Published application
- Kind: A1
- Application number: 16/321,980
- Filed: 2017-07-31
- Published: 2019-06-06
- Earliest claimed: 2016-08-01
- Assignees: Gionas S.R.L.
- Applicants: Gionas S.R.L.
- Inventors: Cristina MAGGIONI
- Web page: https://patentgrep.com/patent/US20190167741A1

## CPC

- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/24: Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A medicament includes a parsley extract for use in the treatment and/or prevention of endometriosis. The medicament may also include an oleander extract.

## Claims

### Claim 1

A medicament comprising a parsley extract for use in the treatment and/or prevention of endometriosis.

### Claim 2 (depends on 1)

The medicament according to claim 1 wherein said parsley extract is an extract chosen from the group consisting of Petroselinum crispum extract, Petroselinum sativum extract and Petroselinum segetum extract.

### Claim 3 (depends on 1)

The medicament according to claim 1, wherein said parsley extract is an extract of the whole parsley plant.

### Claim 4 (depends on 1)

The medicament according to claim 1, wherein said parsley extract is in a form chosen from solution, tablet, capsule, and powder.

### Claim 5 (depends on 1)

The medicament according to claim 1, for oral administration.

### Claim 6 (depends on 1)

The medicament according to claim 1, to be administered for an administration period comprised between 20 and 90 days.

### Claim 7 (depends on 6)

The medicament according to claim 6, wherein said administration period is followed by a further administration period of the medicament comprised between 20 and 90 days.

### Claim 8 (depends on 3)

The medicament according to claim 3, wherein the medicament comprises said parsley extract in the form of a mother tincture and is to be administered in dosage comprised between 10 and 30 drops per day of said parsley extract for an administration period comprised between 20 and 90 days.

### Claim 9 (depends on 8)

The medicament according to claim 8, to be administered in dosage comprised between 5 and 15 drops twice a day of said parsley extract for an administration period comprised between 20 and 90 days.

### Claim 10 (depends on 1)

The medicament according to claim 1, further comprising an oleander extract.

### Claim 11 (depends on 10)

The medicament according to claim 10, wherein said oleander extract is an extract chosen from the group consisting of Nerium oleander extract and Nerium indicum extract.

### Claim 12 (depends on 10)

The medicament according to claim 10, wherein said oleander extract is an extract of oleander leaves.

### Claim 13 (depends on 10)

The medicament according to claim 10, wherein said oleander extract is in a form chosen from solution, tablet, and globules.

### Claim 14 (depends on 13)

The medicament according to claim 13, wherein said oleander extract is in the form of a solution and is obtained by extraction in solvent and further dilution in solvent of the intermediate extract thus obtained thus obtaining a decimal dilution comprised between 4 and 60 DH (Hahnemannian dilution).

### Claim 15 (depends on 10)

The medicament according to claim 10, wherein the medicament is in a pharmaceutical form for oral administration comprising said parsley extract, and said oleander extract, for simultaneous, separate or sequential use, for the treatment and/or the prevention of endometriosis.

### Claim 16 (depends on 10)

The medicament according to claim 10, wherein the medicament comprises said parsley extract and said oleander extract, in a weight ratio between said parsley extract and said oleander extract comprised between 6:1 and 1:1.

### Claim 17 (depends on 10)

The medicament according to claim 10, wherein the medicament comprises said parsley extract in the form of a mother tincture and said oleander extract in a decimal dilution comprised between 4 and 6 DH and is to be administered in a dosage comprised between 10 and 30 drops per day of said parsley extract and in a dosage comprised between 5 and 10 drops per day of said oleander extract for an administration period comprised between 20 and 90 days.

### Claim 18 (depends on 17)

The medicament according to claim 17 to be administered in a dosage comprised between 5 and 15 drops twice a day of said parsley extract and in a dosage comprised between 3 and 5 drops twice a day of said oleander extract for an administration period comprised between 20 and 90 days.

### Claim 19 (depends on 1)

The medicament according to claim 1 to be administered to patients that have previously undergone, following a diagnosis of endometriosis, one or more pre-treatments with one or more agents among anti-inflammatory agent, hepatic and/or renal and/or intestinal drainage agent, antibiotic agent, antimycoplasm agent, antichlamydia agent, antifungal agent and antiviral agent to remove the triggering cause of the inflammatory reaction of the endometriotic cells.

### Claim 20

A kit of parts comprising: a)a parsley extract; and (b) an oleander extract for the treatment and/or prevention of endometriosis.

### Claim 21 (depends on 1)

The method for treating endometriosis comprising administering the medicament according to claim 1 or in patients in need thereof.
