# US 2019/0167740 A1 · Water-soluble cannabinoids and methods of making same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167740 A1 - Document ID: US20190167740A1 - Status: Published application - Kind: A1 - Application number: 16/210,267 - Filed: 2018-12-05 - Published: 2019-06-06 - Earliest claimed: 2017-12-05 - Assignees: Nature's Delivery System, LLC - Inventors: James F. Kane; Keith Butler - Web page: https://patentgrep.com/patent/US20190167740A1 ## CPC - A61K 36/3482: {Cannabis} - A61K 9/107: Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} - A61K 9/14: Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)} - A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol} - A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A process is provided for improving the water solubility of cannabinoids by combining cannabinoids with fat globules obtained from animals, plants, or synthetic chemistry. The animals can be mammals or non-mammals. The plants can be whole plants, tissue cultures, or genetically engineered plants. The fat globules can be used in their natural environment, and/or following processing, and/or as separated or purified particles. ## Claims ### Claim 1 A soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, comprising, in combination, (a) a cannabinoid, hemp oil, cannabis oil or combination thereof, and (b) fat globules from a mammalian source, animal source, plant source, synthetic source, or a combination thereof, wherein components (a) and (b) have been mixed together to form a mixture, solution, emulsion, suspension, powder, paste, or other composition providing a soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof. ### Claim 2 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the source of fat globules comprises raw milk or a processed product of raw milk. ### Claim 3 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the source of fat globules comprises a plant. ### Claim 4 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the source of fat globules comprises a chemically synthesized source. ### Claim 5 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the source of fat globules comprises an animal other than a mammal. ### Claim 6 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, comprises naturally occurring molecules that are purified from hemp, cannabis, or another plant source. ### Claim 7 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, is synthetically prepared. ### Claim 8 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, is derived from genetically engineered microorganisms grown in a controlled environment. ### Claim 9 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, is derived from a genetically engineered plant that is grown either in a field or in a greenhouse. ### Claim 10 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, is derived from plant cell cultures. ### Claim 11 (depends on 1) The soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the cannabinoid, hemp oil, cannabis oil, or combination thereof, comprises hemp oil, cannabis oil, and cannabinoids homogenized together. ### Claim 12 (depends on 1) A method of forming the soluble form of a cannabinoid, hemp oil, cannabis oil, or a combination thereof, of claim 1, wherein the method comprises mixing together components (a) and (b) to effect migration of component (a) into component (b). ### Claim 13 (depends on 12) The method of claim 12, wherein the mixing comprises stirring together at a rate of from about 10 rpm to about 500 rpm. ### Claim 14 (depends on 13) The method of claim 13, wherein the stirring comprises mixing components (a) and (b) together to form a mixture and subjecting the mixture to centrifugation to effect migration of component (a) into component (b). ### Claim 15 (depends on 12) The method of claim 12, wherein component (b) comprises a powder and component (a) is mixed directly with the powder. ### Claim 16 (depends on 15) The method of claim 15, wherein component (a) and component (b) are mixed together at a respective ratio of from 1:1 to 1:10.