# US 2019/0167731 A1 · Traditional Chinese Medicine Composition for Treating Acute Stage of Cerebral Infarction

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- Number: US 2019/0167731 A1
- Document ID: US20190167731A1
- Status: Published application
- Kind: A1
- Application number: 16/265,852
- Filed: 2019-02-01
- Published: 2019-06-06
- Earliest claimed: 2018-08-08
- Assignees: Jiangsu Province Institute of Traditional Chinese Medicine
- Applicants: Jiangsu Province Institute of Traditional Chinese Medicine
- Inventors: Hongquan LIU; Xiaolan CHENG; Jingbo LI; Mingming FANG; Shuting JIANG; Yudi LU; Jie GONG
- Web page: https://patentgrep.com/patent/US20190167731A1

## CPC

- A61K 35/36: Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells (islets of Langerhans A61K35/39)
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 9/1682: {Processes}
- A61K 9/2009: {Inorganic compounds}
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 9/2095: {Tabletting processes}
- A61K 9/4833: {Encapsulating processes; Filling of capsules (mechanical aspects A61J3/07)}
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61K 36/804: Rehmannia
- A61K 36/882: Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61K 2236/331: using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K 2236/37: Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
- A61K 2236/51: Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A traditional Chinese medicine composition for treating acute stage of cerebral infarction. The traditional Chinese medicine composition combines buffalo horns, unprocessed rehmannia roots, red paeony roots, cortex moutan, grassleaf sweelflag rhizome and turmeric root-tuber, and exerts the synergistic effects of the medicines through compatibility, thereby being capable of more effectively clearing away heat and toxic materials, cooling the blood, dissipating blood stasis and inducing resuscitation, and achieving the purpose of treating acute stage of cerebral infarction.

## Claims

### Claim 1

A traditional Chinese medicine composition for treating acute stage of cerebral infarction, characterized in that the composition is prepared from the following raw materials in parts by weight: 10-50 parts of buffalo horns, 10-30 parts of unprocessed rehmannia roots, 10-30 parts of red paeony roots, 10-30 parts of cortex moutan, 6-20 parts of grassleaf sweelflag rhizome and 10-30 parts of turmeric root-tuber.

### Claim 2 (depends on 1)

The traditional Chinese medicine composition for treating acute stage of cerebral infarction according to claim 1, characterized in that the composition is prepared from the following raw materials in parts by weight: 10-30 parts of buffalo horns, 10-20 parts of unprocessed rehmannia roots, 10-20 parts of red paeony roots, 10-20 parts of cortex moutan, 6-15 parts of grassleaf sweelflag rhizome and 10-20 parts of turmeric root-tuber.

### Claim 3 (depends on 1)

The traditional Chinese medicine composition according to claim 1, characterized in that the composition is formulated into a preparation with pharmaceutically acceptable adjuvant materials.

### Claim 4 (depends on 3)

The traditional Chinese medicine composition according to claim 3, characterized in that the preparation formulation is decoction, granules, capsules or tablets.

### Claim 5 (depends on 1)

A preparation method of the traditional Chinese medicine composition for treating acute stage of cerebral infarction of claim 1, characterized in that the method comprises the following steps: mixing herbal pieces of the buffalo horns, the unprocessed rehmannia roots, the red paeony roots and the cortex moutan and performing water extraction; mixing herbal pieces of the grassleaf sweelflag rhizome and the turmeric root-tuber and performing extraction by hot reflux with 70% ethanol; separately concentrating the water extract and the ethanol extract, and performing combining, spray drying and uniform mixing to prepare the traditional Chinese medicine composition.

### Claim 6 (depends on 5)

The method according to claim 5, characterized in that by the water extraction method, water extraction is performed for 2-3 times with 1-3 h each time, and the amount of water is 8-10 times of the total weight of the medicinal materials.

### Claim 7 (depends on 5)

The method according to claim 5, characterized in that by the ethanol extraction method, extraction is performed with 70% ethanol for 2-3 times with 1-2 h each time, and the amount of ethanol is 8-10 times of the total weight of the medicinal materials.

### Claim 8 (depends on 1)

A process for treating acute stage of cerebral infarction comprising a step of administrating to a subject in need a traditional Chinese medicine composition of claim 1.