# US 2019/0167674 A1 · Vigor enhancement via administration of pyrimidine derivatives

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- Number: US 2019/0167674 A1
- Document ID: US20190167674A1
- Status: Published application
- Kind: A1
- Application number: 16/269,243
- Filed: 2019-02-06
- Published: 2019-06-06
- Earliest claimed: 2006-11-28
- Applicants: University of Central Florida Research Foundation, Inc.
- Inventors: Kiminobu SUGAYA; Angel ALVAREZ
- Web page: https://patentgrep.com/patent/US20190167674A1

## CPC

- A61K 31/497: containing further heterocyclic rings
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.

## Claims

### Claim 1

A method of improving skin tone of a subject's skin comprising topically administering to non-wounded skin of said subject a therapeutically effective amount of a composition comprising 2-Piperadino-6-methyl-5-oxo-5,6-dihydro(7H)pyrro-[3,4-d]pyrimidine, or pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein said composition further comprises a surface smoother, a skin plumper, an optical diffuser, a sunscreen, an exfoliation promoter, or an antioxidant, or a combination thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition comprises 2-Piperadino-6-methyl-5-oxo-5,6-dihydro(7H)pyrro-[3,4-d]pyrimidine maleate