# US 2019/0167657 A1 · Nutritional supplement for improving sexual health in men and women

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- Number: US 2019/0167657 A1
- Document ID: US20190167657A1
- Status: Published application
- Kind: A1
- Application number: 15/829,822
- Filed: 2017-12-01
- Published: 2019-06-06
- Earliest claimed: 2017-12-01
- Assignees: Innovus Pharmaceuticals, Inc.
- Applicants: Innovus Pharmaceuticals, Inc.
- Inventors: Bassam Damaj
- Web page: https://patentgrep.com/patent/US20190167657A1

## CPC

- A61K 31/4525: containing a five-membered ring with oxygen as a ring hetero atom
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/175: Amino acids
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/146: {with organic macromolecular compounds}
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 36/67: Piperaceae (Pepper family), e.g. Jamaican pepper or kava
- A61K 47/02: Inorganic compounds
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/38: Cellulose; Derivatives thereof
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/10: for impotence
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to improve sexual function in males and females.

## Claims

### Claim at position 1

1-11. (canceled)

### Claim 12

A unit dosage form suitable for oral administration to a human comprising:
about 500 mg of L-citrulline;
about 250 mg of L-arginine; and
about 1.75 mg of BioPerine®.

### Claim at position 3

13-14. (canceled)

### Claim 15 (depends on 12)

The unit dosage form of claim 12 that further comprises microcrystalline cellulose, silicon dioxide, and magnesium sterate.

### Claim 16

(canceled)

### Claim 17 (depends on 1)

A method to increase NO levels in the blood of a mammal comprising administering a unit dosage form of claim 1 to the mammal.

### Claim 18 (depends on 1)

A method to treat erectile dysfunction in a mammal comprising administering a unit dosage form of claim 1 to the mammal.

### Claim 19 (depends on 1)

A method to improve sexual function in a mammal comprising administering a unit dosage form of claim 1 to the mammal.

### Claim 20 (depends on 1)

A method to improve erection hardness, erection maintenance, frequency of intercourse, partner satisfaction, or overall satisfaction with sexual health in a male human comprising administering a unit dosage form of claim 1 to the male human.

### Claim 21 (depends on 1)

A method to improve lubrication, sexual desire, ability to be aroused or frequency of intercourse, in a female human comprising administering a unit dosage form of claim 1 to the female human.

### Claim 22 (depends on 12)

The unit dosage form of claim 12 wherein the piperine is synthetically produced piperine.

### Claim 23 (depends on 12)

The unit dosage form of claim 12 the piperine is an extract from the fruit of Piper.

### Claim 24 (depends on 12)

The unit dosage form of claim 12 that is formulated as a capsule, powder or liquid.