# US 2019/0167622 A1 · Citrulline-containing fermented milk and method for producing same

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- Number: US 2019/0167622 A1
- Document ID: US20190167622A1
- Status: Published application
- Kind: A1
- Application number: 16/323,814
- Filed: 2017-08-08
- Published: 2019-06-06
- Earliest claimed: 2016-08-09
- Assignees: Meiji Co., Ltd.
- Applicants: Meiji Co., Ltd.
- Inventors: Satoshi Takasugi; Yoshie Saito; Yoshitaka Kawai; Keisuke Furuichi; Masashi Nagata; Hiroyuki Itou
- Web page: https://patentgrep.com/patent/US20190167622A1

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A23C 9/13: using additives
- A23C 9/1322: {Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins}
- A23L 33/175: Amino acids
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 35/20: Milk; Whey; Colostrum
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 25/22: Anxiolytics
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2200/00: Function of food ingredients
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The object of the present invention is to provide: a method for producing a citrulline-containing fermented milk; and a citrulline-containing fermented milk produced by the method. The method can prevent milk quality from deteriorating, even when citrulline is added, and the citrulline-containing fermented milk has the effect of improving blood flow. The present invention pertains to: a method for producing a citrulline-containing fermented milk, the method comprising heat-treating a raw material mix that contains citrulline, and fermenting the heat-treated raw material mix, wherein the content of citrulline in the raw material mix that is heat-treated is 0.1-4%; and a fermented milk produced by the method.

## Claims

### Claim 1

A method for producing citrulline-containing fermented milk, comprising heat-treating a raw material mix containing citrulline, and fermenting the heat-treated raw material mix, wherein the citrulline content in the raw material mix to be heat treated is 0.1 to 4%.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the raw material mix comprises citrulline derived from citrulline-producing microorganisms.

### Claim 3 (depends on 1)

A fermented milk produced by the method according to claim 1.

### Claim 4 (depends on 3)

The fermented milk according to claim 3, wherein the fermented milk is yogurt.

### Claim 5 (depends on 3)

The fermented milk according to claim 3, wherein the citrulline content in the fermented milk is 0.3 to 0.5%.

### Claim 6 (depends on 3)

The fermented milk according to claim 3, which has one or more uses selected from the group consisting of improvement of blood flow, improvement of sensitivity to cold, improvement of skin quality, and normalization of mental condition.