# US 2019/0167607 A1 · Uses of a carotenoid in the treatment or prevention of stress induced conditions

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- Number: US 2019/0167607 A1
- Document ID: US20190167607A1
- Status: Published application
- Kind: A1
- Application number: 16/092,848
- Filed: 2017-04-11
- Published: 2019-06-06
- Earliest claimed: 2016-04-11
- Assignees: Greenaltech, S.L.
- Applicants: Greenaltech, S.L.
- Inventors: Eugenia RUIZ CANOVAS; Xavier ÁLVAREZ MICÓ; Olga DURANY TURK; Jordi SEGURA DE YEBRA; Jaume MERCADÉ ROCA
- Web page: https://patentgrep.com/patent/US20190167607A1

## CPC

- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/15: Vitamins
- A61K 8/31: Hydrocarbons
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 31/01: Hydrocarbons
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/065: Diphenyl-substituted acyclic alcohols
- A61K 31/336: having three-membered rings, e.g. oxirane, fumagillin
- A61K 31/343: condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 19/10: for osteoporosis
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 35/00: Antineoplastic agents
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2250/211: Carotene, carotenoids
- A61K 36/00: Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines {(antigens from pollen A61K39/36)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention relates to a carotenoid for use in the treatment or prevention of stress induced conditions, and in particular it relates to the treatment or prevention of a disease mediated by glucocorticoid receptor activity. The invention also relates to a cosmetic method for preventing premature-aging of skin in a subject which comprises administering a carotenoid to said subject. Finally, the invention relates to a method for modulating the activity of a glucocorticoid receptor comprising contacting the receptor with a carotenoid.

## Claims

### Claim at position 1

1-24. (canceled)

### Claim 25

A method for the treatment or prevention of a disease mediated by glucocorticoid receptor activity, which comprises administering a carotenoid wherein the carotenoid is selected from the group consisting of xanthophylls and carotenes, and wherein
the xanthophyll is selected from the group consisting of α-cryptoxantin, β-cryptoxantin, adonirubin, adonixanthin, alloxanthin, amarouciaxanthin A, antheraxanthin, auroxanthin, caloxanthin, capsanthin, capsanthin-5-6-epoxide, capsorubin, crocoxanthin, diadinoxant, diatoxanthin, echinenone, fucoxanthin, fucoxanthinol, iso-fucoxanthin, iso-fucoxanthinol, lutein, luteoxanthin, mutatoxanthin, neoxanthin, nostoxanthin, violaxanthin, and combinations thereof; and
the carotene is selected from the group consisting of α-carotene, γ-carotene, δ-carotene, ϵ-carotene, ζ-carotene, neurosporene and combinations thereof.

### Claim 26 (depends on 25)

The method according to claim 25 wherein the disease characterized by an undesired glucocorticoid activity is selected from the group consisting of cortisol-induced immunosuppression, cortisol-induced insulin resistance, altered skin barrier homeostasis, Cushing's syndrome, subclinical Cushing's syndrome, subclinical hypercortisolemia, metabolic syndrome, inflammatory bowel disease, muscle wasting and muscle dystrophy, insomnia associated to circadian rhythm disorders, hypertension, water retention, cortisol-induced DNA damage, migraine, psychosis, appetite reduction, depression, stress disorders and cognitive disorders such as Alzheimer's disease catatonia, amyotrophic lateral sclerosis, delirium, post-traumatic stress disorders, impaired memory retrieval, borderline personality disorder, or wherein the disease is cancer in which case the carotenoid is used as adjuvant in the therapy with paclitaxel or eribulin.

### Claim 27

A cosmetic method for preventing premature-aging of skin in a subject, wherein the premature aging of skin is caused by corticoids, which comprises administering a carotenoid to said subject, with the proviso that the carotenoid is not astaxanthin or beta-carotene, wherein the carotenoid is selected from the group of xanthophylls and carotenes, and wherein
the xanthophyll is selected from the group consisting of α-cryptoxantin. β-cryptoxantin, adonirubin, adonixanthin, alloxanthin, amarouciaxanthin A, antheraxanthin, auroxanthin, caloxanthin, canthaxanthin, capsanthin, capsanthin-5-6-epoxide, capsorubin, crocoxanthin, diadinoxanthin, diatoxanthin, echinenone, fucoxanthin, fucoxanthinol, iso-fucoxanthin, isofucoxanthinol, lutein, luteoxanthin, mutatoxanthin, neoxanthin, nostoxanthin, violaxanthin and combinations thereof; and
the carotene is selected from the group consisting of α-carotene, γ-carotene, δ-carotene, ϵ-carotene, ζ-carotene, lycopene, neurosporene, phytoene, phytofluene and combinations thereof.

### Claim 28

A method for modulating an activity of a glucocorticoid receptor comprising contacting the receptor with a carotenoid, with the proviso that the carotenoid is not astaxanthin or beta-carotene.

### Claim 29 (depends on 28)

The method according to claim 28 wherein the carotenoid is administered to a subject at risk of or experiencing symptoms of a disease characterized by increased glucocorticoid receptor activity.

### Claim 30 (depends on 28)

The method according to claim 28 wherein the carotenoid is administered as part of a food, a drink, a nutraceutical composition, pharmaceutical composition, functional food, functional nutrition product, medical food, medical nutrition product, dietary supplement or botanical drug.

### Claim 31 (depends on 29)

The method according to claim 29 wherein the symptoms of a disease characterized by increased glucocorticoid receptor activity is selected from the group consisting of impaired cognitive functions, depression, jet-lag, stress disorders, cardiovascular disorders and osteoporosis.

### Claim 32 (depends on 25)

The method according to claim 25 wherein the carotenoid is a xanthophyll selected from the group consisting of α-cryptoxantin, β-cryptoxantin, adonirubin, adonixanthin, alloxanthin, amarouciaxanthin A, antheraxanthin, auroxanthin, caloxanthin, capsanthin, capsanthin-5-6-epoxide, capsorubin, crocoxanthin, diadinoxanthin, diatoxanthin, echinenone, fucoxanthin, fucoxanthinol, iso-fucoxanthin, iso-fucoxanthinol, lutein, luteoxanthin, mutatoxanthin, neoxanthin, nostoxanthin, violaxanthin, and combinations thereof.

### Claim 33 (depends on 32)

The method according to claim 32 wherein the xantophyll is neoxanthin, fucoxanthin, isofuncoxanthinol or lutein.

### Claim 34 (depends on 25)

The method according to claim 25 wherein the carotenoid is a carotene selected from the group consisting of α-carotene, γ-carotene, δ-carotene, ϵ-carotene, ζ-carotene, lycopene, neurosporene, and combinations thereof.

### Claim 35 (depends on 27)

The method according to claim 27 wherein the carotenoid is a xanthophyll. is selected from the group consisting of α-cryptoxantin, β-cryptoxantin, adonirubin, adonixanthin, alloxanthin, amarouciaxanthin A, antheraxanthin, auroxanthin, caloxanthin, capsanthin, capsanthin-5-6-epoxide, capsorubin, crocoxanthin, diadinoxanthin, diatoxanthin, echinenone, fucoxanthin, fucoxanthinol, iso-fucoxanthin, iso-fucoxanthinol, lutein, luteoxanthin, mutatoxanthin, neoxanthin, nostoxanthin, violaxanthin, and combinations thereof.

### Claim 36 (depends on 35)

The method according to claim 35 wherein the xantophyll is neoxanthin, fucoxanthin, isofuncoxanthinol or lutein.

### Claim 37 (depends on 27)

The method according to claim 27 wherein the carotenoid is a carotene
selected from the group consisting of α-carotene, γ-carotene, δ-carotene, ϵ-carotene, ζ-carotene, lycopene, neurosporene, and combinations thereof.

### Claim 38 (depends on 28)

The method according to claim 28 wherein the carotenoid is a xanthophyll.
selected from the group consisting of α-cryptoxantin, β-cryptoxantin, adonirubin, adonixanthin, alloxanthin, amarouciaxanthin A, antheraxanthin, auroxanthin, caloxanthin, capsanthin, capsanthin-5-6-epoxide, capsorubin, crocoxanthin, diadinoxanthin, diatoxanthin, echinenone, fucoxanthin, fucoxanthinol, iso-fucoxanthin, iso-fucoxanthinol, lutein, luteoxanthin, mutatoxanthin, neoxanthin, nostoxanthin, violaxanthin, and combinations thereof.

### Claim 39 (depends on 38)

The method according to claim 38, wherein the xantophyll is neoxanthin, fucoxanthin, isofuncoxanthinol or lutein.

### Claim 40 (depends on 28)

The method according to claim 28 wherein the carotenoid is a carotene selected from the group consisting of α-carotene, γ-carotene, δ-carotene, ϵ-carotene, ζ-carotene, lycopene, neurosporene, and combinations thereof.

### Claim 41 (depends on 25)

The method according to claim 25 wherein the carotenoid is provided as an algal, fungal or plant extract.

### Claim 42 (depends on 27)

The method according to claim 27 wherein the carotenoid is provided as an algal, fungal or plant extract.

### Claim 43 (depends on 28)

The method according to claim 28 wherein the carotenoid is provided as an algal, fungal or plant extract.

### Claim 44 (depends on 28)

The method according to claim 28 wherein the subject is a human.