# US 2019/0167606 A1 · Dermatitis treatment

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- Number: US 2019/0167606 A1
- Document ID: US20190167606A1
- Status: Published application
- Kind: A1
- Application number: 16/117,148
- Filed: 2018-08-30
- Published: 2019-06-06
- Earliest claimed: 2012-11-27
- Assignees: Avexxin AS
- Applicants: Avexxin AS
- Inventors: Berit Johansen
- Web page: https://patentgrep.com/patent/US20190167606A1

## CPC

- A61K 31/121: acyclic
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of formula (I) R-L-CO—X (I) (wherein R is a C10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO2, said hydrocarbon group comprising at least 4 non-conjugated double bonds; L is a linking group forming a bridge of 1 to 5 atoms between the R group and the carbonyl CO wherein L comprises at least one heteroatom in the backbone of the linking group; and X is an electron withdrawing group) or a salt thereof for use in the treatment of dermatitis.

## Claims

### Claim at position 1

1-18. (canceled)

### Claim 19

A method of treating dermatitis comprising administering to an animal in need thereof an effective amount of a compound of formula (I′):
R—Y1-Y2-CO—X (I′),
or a salt thereof, wherein in formula (I′):
R is a C10-24 unsaturated hydrocarbon group comprising at least 4 non-conjugated double bonds;
X is an electron withdrawing group;
Y1 is selected from O, S, NH, N(C1-6-alkyl), SO or SO2; and
Y2 is (CH2)n or CH(C1-6alkyl), where n is 1 to 3.

### Claim 20 (depends on 19)

A method of claim 19 wherein the hydrocarbon group R has 5 to 7 double bonds.

### Claim 21 (depends on 19)

A method of claim 19 wherein in the hydrocarbon group R all double bonds are in the cis configuration or wherein in the hydrocarbon group all double bonds are in the cis configuration except the double bond nearest the carbonyl.

### Claim 22 (depends on 19)

A method of claim 19 wherein the R group comprises 17 to 19 carbon atoms.

### Claim 23 (depends on 19)

A method of claim 19 wherein X is CHal3.

### Claim 24 (depends on 23)

A method of claim 23 wherein X is CF3.

### Claim 25 (depends on 19)

A method of claim 19 wherein the compound of formula (I) has the formula:
wherein X is an electron withdrawing group.

### Claim 26 (depends on 25)

A method of claim 25 wherein X is CF3.

### Claim 27 (depends on 19)

A method of claim 19 wherein n is 1.

### Claim 28 (depends on 19)

A method of claim 19 wherein the compound of formula (I) is
or a salt thereof.

### Claim 29 (depends on 19)

A method of claim 19 wherein the compound is applied topically.

### Claim 30 (depends on 19)

A method of claim 19 wherein the animal is a mammal.

### Claim 31 (depends on 19)

A method of claim 19 wherein the animal is a human.

### Claim 32

A method of treating dermatitis comprising administering to a mammal in need thereof an effective amount of a compound of formula
or a salt thereof.

### Claim 33 (depends on 32)

A method of claim 32 wherein the mammal is a human.

### Claim 34 (depends on 32)

A method of claim 32 wherein the compound is applied topically.