# US 2019/0167561 A1 · Methods and compositions for reducing the graying of hair > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167561 A1 - Document ID: US20190167561A1 - Status: Published application - Kind: A1 - Application number: 16/325,506 - Filed: 2017-08-11 - Published: 2019-06-06 - Earliest claimed: 2016-08-15 - Assignees: Natura Cosmeticos S.A.; The General Hospital Corporation - Applicants: Natura Cosmeticos SA; The General Hospital Corporation - Inventors: Ana Paula Pedroso Oliveira; Gabriela Placoná Diniz; Juliana Carvalhães Lago; Kelen Fabiola Arroteia; David E. Fisher - Web page: https://patentgrep.com/patent/US20190167561A1 ## CPC - A61K 8/9789: Magnoliopsida [dicotyledons] - A61K 8/042: {Gels} - A61K 8/062: {Oil-in-water emulsions} - A61K 8/064: {Water-in-oil emulsions, e.g. Water-in-silicone emulsions} - A61K 8/34: Alcohols - A61K 8/447: {containing sulfur} - A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin} - A61K 8/645: {Proteins of vegetable origin; Derivatives or degradation products thereof} - A61K 8/678: {Tocopherol, i.e. vitamin E} - A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone - A61K 8/922: {of vegetable origin} - A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof - A61K 8/9728: Fungi, e.g. yeasts - A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00) - A61Q 5/10: Preparations for permanently dyeing the hair - A61Q 19/08: Anti-ageing preparations - A61K 2800/522: Antioxidants; Radical scavengers - A61K 2800/5922: At least two compounds being classified in the same subclass of A61K8/18 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract This disclosure relates to methods of reducing or inhibiting the graying of hair by topically applying various cosmetic formulations to hair follicles and/or to the skin overlying hair follicles. The formulations applied in these methods include green tea extract and one or more additional plant extracts, in addition to one or more cosmetically acceptable carriers and/or accessory ingredients. ## Claims ### Claim 1 A method for reducing or inhibiting the graying of hair, the method comprising topically applying a cosmetically effective amount of a formulation to hair follicles and/or to the skin overlying hair follicles one or more times per day, wherein the formulation comprises a combination of a green tea extract; one or more of the group consisting of aroeira (Schinus terebinthifolius) extract, coffee extract, vitamin E, grape seed oligomeric proanthocyanidins (OPC), cocoa extract, Castanea sativa seed extract, hydrolyzed Candida saitoana extract and soybean protein; and one or more cosmetically acceptable carriers comprising an aqueous gel, alcoholic gel, ointment, oil, alcoholic or aqueous fluid, water-in-oil emulsion, oil-in-water emulsion, and a water-in-silicone emulsion. ### Claim 2 (depends on 1) The method of claim 1, wherein the formulation further comprises one or more cosmetically acceptable accessory ingredients. ### Claim 3 (depends on 2) The method of claim 2, wherein the cosmetically acceptable accessory ingredients are selected from the group consisting of xanthan gum, glycerine, EDTA, sodium benzoate, phenoxyethanol, 2-hydroxy fatty alcohol alkoxylate, sodium polyacrylate, polysorbate 20, BHT, disaccharidic gums, ethylhexylglycerin, carbomer, butyleneglycol, acrylate polymers, PEG-40 hydrogenated castor oil, methylisothiazolinone, methylchloroisothiazolinone, propylene glycol, potassium sorbate, polyglyceryl caprylate, fragrance and water. ### Claim 4 (depends on 1) The method of claim 1, wherein the combination comprises between about 0.1% and 15% of the formulation. ### Claim 5 (depends on 1) The method of claim 1, wherein the green tea extract comprises about 0.001% to about 0.5% of the formulation. ### Claim 6 (depends on 1) The method of claim 1, wherein aroeira (Schinus terebinthifolius) extract is included and the aroeira (Schinus terebinthifolius) extract comprises about 0.001% to about 2.5% of the formulation. ### Claim 7 (depends on 1) The method of claim 1, wherein coffee extract is included and the coffee extract comprises about 0.01% to about 1% of the formulation. ### Claim 8 (depends on 1) The method of claim 1, wherein vitamin E is included and the vitamin E comprises about 0.01% to about 3% of the formulation. ### Claim 9 (depends on 1) The method of claim 1, wherein grape seed oligomeric proanthocyanidins (OPC) is included and the grape seed oligomeric proanthocyanidins (OPC) comprises about 0.01% to about 1% of the formulation. ### Claim 10 (depends on 1) The method of claim 1, wherein cocoa extract is included and the cocoa extract comprises about 0.01% to about 1% of the formulation. ### Claim 11 (depends on 1) The method of claim 1, wherein Castanea sativa seed extract is included and the Castanea sativa seed extract comprises about 0.2% to about 5% of the formulation. ### Claim 12 (depends on 1) The method of claim 1, wherein hydrolyzed Candida saitoana extract is included and the hydrolyzed Candida saitoana extract comprises about 0.08% to about 3% of the formulation. ### Claim 13 (depends on 1) The method of claim 1, wherein soybean protein is included and the soybean protein comprises about 0.5% to about 15% of the formulation. ### Claim 14 (depends on 3) The method of claim 3, wherein: xanthan gum is included and the xanthan gum comprises about 0.001% to about 5% of the formulation; glycerin is included and the glycerin comprises about 0.001% to about 5% of the formulation; EDTA is included and the EDTA comprises about 0.001% to about 5% of the formulation; sodium benzoate is included and the sodium benzoate comprises about 0.001% to about 5% of the formulation; phenoxyethanol is included and the phenoxyethanol comprises about 0.001% to about 5% of the formulation; 2-hydroxy fatty alcohol alkoxylate is included and the 2-hydroxy fatty alcohol alkoxylate comprises about 0.001% to about 5% of the formulation; sodium polyacrylate is included and the sodium polyacrylate comprises about 0.001% to about 5% of the formulation; polysorbate 20 is included and the polysorbate 20 comprises about 0.001% to about 5% of the formulation; and/or BHT is included and the BHT comprises about 0.001% to about 5% of the formulation. ### Claim 15 (canceled) ### Claim 16 (canceled) ### Claim 17 (canceled) ### Claim 18 (canceled) ### Claim 19 (canceled) ### Claim 20 (canceled) ### Claim 21 (canceled) ### Claim 22 (canceled) ### Claim 23 (depends on 3) The method of claim 3, wherein fragrance is included and the fragrance comprises about 0.001% to about 5% of the formulation. ### Claim 24 (depends on 3) The method of claim 3, wherein water is included and the water comprises about 0.001% to about 5% of the formulation. ### Claim 25 (depends on 1) The method of claim 1, wherein the formulation comprises about 0.1% of green tea extract, about 0.25% of aroeira (Schinus terebinthifolius) extract and about 0.1% of grape seed oligomeric proanthocyanidins (OPC). ### Claim 26 (depends on 1) The method of claim 1, wherein the formulation comprises about 2.2% of Castanea sativa seed extract, about 1.65% of hydrolyzed Candida saitoana extract, about 0.05% of cocoa extract and about 5.5% soy protein. ### Claim 27 (depends on 1) The method of claim 1, wherein the formulation further comprises N-acetyl-cysteine. ### Claim 28 (depends on 1) The method of claim 1, wherein the formulation reduces oxidative cell stress and/or inhibits melanocyte stem cell depletion. ### Claim 29 (canceled)