# US 2019/0167539 A1 · DMS (derma membrane structure) in Foam Creams

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- Number: US 2019/0167539 A1
- Document ID: US20190167539A1
- Status: Published application
- Kind: A1
- Application number: 16/270,929
- Filed: 2019-02-08
- Published: 2019-06-06
- Earliest claimed: 2007-06-19
- Inventors: Thomas Neubourg
- Web page: https://patentgrep.com/patent/US20190167539A1

## CPC

- A61K 8/046: {Aerosols; Foams}
- A61K 8/0295: {Liquid crystals}
- A61K 8/36: Carboxylic acids; Salts or anhydrides thereof
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/553: {Phospholipids, e.g. lecithin}
- A61P 17/00: Drugs for dermatological disorders
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/005: {Preparations for sensitive skin}
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/33: Free of surfactant
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention relates to a foam formulation comprising an emulsion, comprising an oil phase and a water phase, the oil phase comprising at least one membrane-forming substance forming a lamellar membrane in the foam formulation.

## Claims

### Claim 1

A foam formulation comprising an emulsion which comprises an oil phase and a water phase, wherein the oil phase comprises at least one membrane-forming substance forming a lamellar membrane in the foam formulation.

### Claim 2 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion is an oil-in-water type emulsion.

### Claim 3 (depends on 1)

The foam formulation according to claim 1, wherein the at least one membrane-forming substance comprises a lipid.

### Claim 4 (depends on 3)

The foam formulation according to claim 3, wherein said lipid is a triglyceride that comprises caprylic acid/caprinic acid triglyceride.

### Claim 5 (depends on 3)

The foam formulation according to claim 3, wherein the lipid comprises a phospholipid.

### Claim 6 (depends on 5)

The foam formulation according to claim 5, wherein said phospholipid is lecithin or lecithin that comprises hydrated lecithin.

### Claim 7 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion further comprises at least one thickening agent which is preferably selected from the group consisting of hydroxypropylmethyl cellulose, xanthan gum and mixtures thereof.

### Claim 8 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion further comprises a stablilizer.

### Claim 9 (depends on 8)

The foam formulation according to claim 8, wherein the stabilize comprises pentylene glycol.

### Claim 10 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion further comprises shea butter, glycerol, squalan, ceramide, preferably ceramide 3 or mixtures thereof.

### Claim 11 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion further comprises an oil or Oils lubricating substance.

### Claim 12 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion further comprises at least one active agent.

### Claim 13 (depends on 12)

The foam formulation according to claim 12, wherein the active agent is selected from the group consisting ofhydroviton, pyrrolidone carbonic acid and salts thereof, lactic acid and salts thereof, glycerol, sorbitol, propylene glycol, urea, collagen, elastin, silk protein, hyaluronic acid, pentavitin, ceramides, panthenol, niacin, a-tocopherol and esters thereof, vitamin A, vitamin C, galates, polyphenols, panthenol, bisabolol, phytosteroles, glycocorticoides, antibiotics, analgetics, antiphlogistics, antirheumatics, antiallergics, antiparasitatics, antipruriginosics, antipsoriatics, retinoids, local anaesthetics, therapeutic agents for the veins, ceratolytics, hyperemisic compounds, coronary therapeutics (nitrates/nitro-compounds), virus statics, cytostatics, hormones, agents promoting wound healing, growth factors, enzyme preparations, insecticides and plant material such as e.g. plant extracts of algae, aloe, amica, barber's rash, comfrey, birch, stinging nettle, calendula, oak, ivy, witch hazel, henna, hops, camomile, ruscus, peppermint, marigold, rosemary, sage, green tea, tea tree, horsetail, thyme walnut and mixtures thereof.

### Claim 14 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion is a substantially emulsifier-free emulsion.

### Claim 15 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion is free of emulsifier.

### Claim 16 (depends on 3)

The foam formulation according to claim 3, wherein the lipid comprises bioidentical fats.

### Claim 17 (depends on 1)

The foam formulation according to claim 1, wherein the formulation is a foam cream.

### Claim 18 (depends on 1)

The foam formulation according to claim 1, wherein the emulsion comprises at least one phospholipid and at least one liquid wax ester.

### Claim 19 (depends on 18)

The foam formulation according to claim 18, wherein the phospholipid comprises lecithin, or a triglyceride.

### Claim 20 (depends on 1)

The foam formulation according to claim 1, wherein the membrane-forming substance is not soluble in water.

### Claim 21 (depends on 1)

The foam formulation according to claim 1, wherein the membrane-forming substance has a HLB value of more than 8.

### Claim 22 (depends on 1)

The foam formulation according to claim 1, wherein said formulation is a skin care agent.

### Claim 23 (depends on 1)

The Use of a foam formulation according to claim 1, wherein said formulation is a skin cleaning agent.

### Claim 24 (depends on 1)

The formulation according to claim 1, wherein said formulation is a sunscreen.

### Claim 25 (depends on 1)

A method of making a composition that comprises a cosmetic agent, medical agent or pharmaceutical, wherein said method comprises the use of a formulation according to claim 1 for the for the manufacture of said a cosmetic agent, medical agent or pharmaeeutical composition.

### Claim 26

A method for producing a foam formulation comprising the following steps:
a) Producing an emulsion, and
b) Filling the emulsion and propellant into a pressurized container, or
filling the emulsion into a container other than a pressurized container that upon dispensing of the emulsion generates a foam.

### Claim 27 (depends on 1, 26)

The method according to claim 26 wherein said foam formulation is the formulation according to claim 1.

### Claim 28 (depends on 27)

The method according to claim 27, wherein producing the emulsion comprises the steps:
(1) Providing an oil phase optionally comprising at least one membrane-forming substance that forms a lamellar membrane in the formulation,
(2) Providing a water phase,
(3) Adding and homogenizing both phases,
(4) Optionally adding at least one or at least one further membrane-forming sub stance,
(5) Optionally homogenizing, in order to obtain an emulsion,
wherein in at least one of the steps (1) or (4) at least one membrane-forming substance is comprised that forms a lamellar membrane in the formulation.

### Claim 29 (depends on 28)

The method according to claim 28, wherein the oil phase and the water phase are homogenized at a temperature between about 40 up to about 90° C.

### Claim 30 (depends on 28)

The method according to claim 28, wherein the emulsion comprises a thickening agent, further comprising the steps:
(6) Providing an aqueous solution of thickening agent,
(7) Mixing the solution of thickening agent with the emulsion.

### Claim 31 (depends on 28)

The method according to claim 28, wherein the foam formulation contains 10 weight percent propellant.

### Claim 32 (depends on 28)

The method according to claim 28, wherein homogenizing is carried out under high energy input.

### Claim 33 (depends on 28)

The method according to claim 28, wherein homogenizing is carried out at a pressure of about 50,000 to about 250,000 kilopascal.
