# US 2019/0167452 A1 · Physiologically active implantable biomaterials having engineered functional surfaces > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167452 A1 - Document ID: US20190167452A1 - Status: Published application - Kind: A1 - Application number: 16/209,219 - Filed: 2018-12-04 - Published: 2019-06-06 - Earliest claimed: 2017-12-05 - Assignees: Vactronix Scientific, LLC - Applicants: Vactronix Scientific, LLC - Inventors: Julio C. Palmaz; Christian G. Palmaz; Scott P. Carpenter - Web page: https://patentgrep.com/patent/US20190167452A1 ## CPC - A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) - A61B 5/0031: {Implanted circuitry} - A61B 5/388: Nerve conduction study, e.g. detecting action potential of peripheral nerves - A61B 5/6847: {mounted on an invasive device} - A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)} - A61B 5/6862: {Stents} - A61N 1/05: for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) - A61N 1/36: for stimulation - A61N 1/378: Electrical supply - C23C 14/04: Coating on selected surface areas, e.g. using masks - A61B 5/287: Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS] - A61B 5/296: for electromyography [EMG] - A61B 5/6868: {Brain} - A61B 5/6869: {Heart} - A61B 5/6876: {Blood vessel} - A61B 5/6877: {Nerve} - A61B 2560/0219: of externally powered implanted units - A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)} - A61F 2/07: Stent-grafts - A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61N 1/3605: {Implantable neurostimulators for stimulating central or peripheral nerve system} - A61N 1/37229: {Shape or location of the implanted or external antenna} - A61N 1/37514: {Brain implants} - A61N 1/37516: {Intravascular implants} - A61N 1/3756: {Casings with electrodes thereon, e.g. leadless stimulators} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - C23C: COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL (making metal-coated products by extrusion B21C23/22; covering with metal by connecting pre-existing layers to articles, see the relevant places, e.g. B21D39/00, B23K; metallising of glass C03C; metallising mortars, concrete, artificial stone, ceramics or natural stone C04B41/00; enamelling of, or applying a vitreous layer to, metals C23D; treating metal surfaces or coating of metals by electrolysis or electrophoresis C25D; single-crystal film growth C30B; by metallising textiles D06M11/83; decorating textiles by locally metallising D06Q1/04) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract Wireless implantable medical devices, in particular stents, for operably coupling to and functionally interfacing with tissue, such as vascular tissue, adjacent to the implantable medical device, having integrally formed electronic circuitry configured to sense and/or stimulate tissue, such as nerves, adjacent to or in proximity to the situs of the implantable medical device and capable of transmitting signals from the stent to a remote receiver to interrogate conditions in the body or receive signals to stimulate tissue. ## Claims ### Claim 1 A wireless physiologically active implantable medical device, comprising a scaffold configured to be delivered to and implanted at a situs in a mammalian body, the scaffold further comprising a plurality of structural supports, at least one electronic circuit integrally formed as part of at least one structural support of the plurality of structural supports, at least one structural support of the plurality of structural supports further comprising at least one integrally formed region electrically coupling the at least one electronic circuit to tissue proximate the situs in a mammalian body. ### Claim 2 (depends on 1) The wireless physiologically active implantable medical device of claim 1, wherein the scaffold is a stent. ### Claim 3 (depends on 2) The wireless physiologically active implantable medical device of claim 2, wherein the plurality of structural supports form a tubular structure of the stent. ### Claim 4 (depends on 3) The wireless physiologically active implantable medical device of claim 3, wherein at least some structural supports of the plurality of structural supports further include at least one recess in an abluminal surface of the at least some structural supports of the plurality of structural supports. ### Claim 5 (depends on 4) The wireless physiologically active implantable medical device of claim 4, wherein the at least one electronic circuit is integrally formed within the at least one recess. ### Claim 6 (depends on 4) The wireless physiologically active implantable medical device of claim 4, wherein the at least one electronic circuit further comprises an integrated circuit. ### Claim 7 (depends on 5) The wireless physiologically active implantable medical device of claim 5, wherein the at least one integrally formed region configured to electrically couple the at least one electronic circuit to tissue at the situs further comprises a raised topography comprising a plurality of micro-needles. ### Claim 8 (depends on 7) The wireless physiologically active implantable medical device of claim 7, wherein the plurality of micro-needles is configured to receive electrical signals from the electronic circuit and communicate the electrical signals to tissue in the mammalian body. ### Claim 9 (depends on 5) The wireless physiologically active implantable medical device of claim 5, wherein the at least one electronic circuit is configured as at least one of an antenna, a transmitter, a power source and/or an electrode. ### Claim 10 (depends on 6) The wireless physiologically active implantable medical device of claim 6, wherein the integrated circuit further comprises an LC circuit. ### Claim 11 (depends on 9) The wireless physiologically active implantable medical device of claim 9, wherein the stent is an antenna operably coupled to the at least one electronic circuit. ### Claim 12 (depends on 5) The wireless physiologically active implantable medical device of claim 5, further comprising at least one electrode in electrical communication with the at least one electronic circuit. ### Claim 13 (depends on 6) The wireless physiologically active implantable medical device of claim 6, further comprising at least one electrode in electrical communication with the integrated circuit. ### Claim 14 (depends on 5) The wireless physiologically active implantable medical device of claim 5, wherein the at least one electronic circuit is positioned within a width and depth of the at least one structural support of the plurality of structural supports. ### Claim 15 (depends on 1) The wireless physiologically active implantable medical device of claim 1, wherein each structural support of the plurality of structural supports has a thickness less than or equal to 75 microns. ### Claim 16 (depends on 15) The wireless physiologically active implantable medical device of claim 15, wherein each structural support of the plurality of structural supports has a width less than or equal to 75 microns. ### Claim 17 (depends on 7) The wireless physiologically active implantable medical device of claim 7, wherein each micro-needle of the plurality of micro-needles has a height of less than or equal to about 10.0 microns. ### Claim 18 A method of making a wireless physiologically active implantable medical device, comprising the steps of: a. Providing a substrate for forming the wireless physiologically active implantable medical device; b. Vacuum depositing a device forming material onto the substrate; c. Masking portions of the deposited device forming material to define recesses regions to be formed on the device forming material; d. Forming recesses in a surface of the device forming material; e. Depositing at least one electrical component layer of a plurality of electrical component layers into the recesses; and f. Forming surface features on a surface of at least some of the electrical component layers of the plurality of electrical component layers. ### Claim 19 (depends on 18) The method of claim 18, wherein step b further comprises the step of depositing a shape memory metal. ### Claim 20 (depends on 19) The method of claim 19, further comprising the step of depositing an electrically conductive layer coupling at least one electrical component layer of the plurality of electrical component layers to the device forming material. ### Claim 21 (depends on 20) The method of claim 20, further comprising the step of depositing an electrically conductive layer coupling at least one electrical component layer of the plurality of electrical component layers to another electrical component layer. ### Claim 22 (depends on 18) The method of claim 18, wherein step e further comprises 3D printing at least one electrical component layer of a plurality of electrical component layers into the recesses.