# US 2019/0167410 A1 · Methods, systems and devices for treatment of cerebrospinal venous insufficiency and multiple sclerosis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167410 A1 - Document ID: US20190167410A1 - Status: Published application - Kind: A1 - Application number: 16/264,842 - Filed: 2019-02-01 - Published: 2019-06-06 - Earliest claimed: 2010-02-10 - Assignees: Apertomed L.L.C. - Applicants: Apertomed LLC - Inventors: Joshua Makower; Earl A. Bright, II; Theodore M. Bender; Joseph Cantanese, III; John Y. Chang; Thomas King; Clinton Slone; Theodore C. Lamson; Aziz Imraan - Web page: https://patentgrep.com/patent/US20190167410A1 ## CPC - A61F 2/06: Blood vessels - A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other - A61F 2/885: {comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis} - A61F 2/89: the wire-like elements comprising two or more adjacent rings flexibly connected by separate members - A61F 2002/825: {having longitudinal struts} - A61F 2220/0008: Fixation appliances for connecting prostheses to the body - A61F 2220/0016: with sharp anchoring protrusions, e.g. barbs, pins, spikes - A61F 2230/0054: V-shaped - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract Methods and devices for relieving stenoses in, or otherwise improving blood flow through, body lumens. Although applicable in a variety of different body lumens, the methods and devices of this invention are specifically useable for relieving stenoses in, or otherwise improving blood flow through, veins which drain blood from the brain for treatment of multiple sclerosis or other neurodegenerative disorders that are caused, triggered or exacerbated by venous occlusion or venous insufficiency. ## Claims ### Claim 1 (canceled) ### Claim 2 (canceled) ### Claim 3 (canceled) ### Claim 4 (canceled) ### Claim 5 (canceled) ### Claim 6 (canceled) ### Claim 7 (canceled) ### Claim 8 (canceled) ### Claim 9 (canceled) ### Claim 10 A stent device comprising: at least one self-expanding stent member; and at least one deformable constraining member connected to the at least one expanding stent member; the at least one self-expanding stent member being initially deployable in a collapsed configuration and thereafter self-expandable to a first expanded configuration, the at least one deformable constraining member being operative to diametrically constrain the at least one self-expanding stent member so that it does not self expand beyond the first expanded configuration; and all or part of the at least one deformable constraining member being thereafter deformable to a deformed configuration that allows all or part of the at least one self-expanding stent member to further expand to a second expanded configuration. ### Claim 11 (depends on 10) A stent device according to claim 10 wherein the at least one self-expanding stent member comprises one or more self-expanding rings. ### Claim 12 (depends on 10) A stent device according to claim 10 wherein the at least one self-expanding stent member comprises one or more self-expanding zig-zag rings. ### Claim 13 (depends on 10) A stent device according to claim 10 wherein the at least one self-expanding stent member comprises one or more self-expanding mesh rings. ### Claim 14 (depends on 10) A stent device according to claim 10 wherein the at least one deformable constraining member comprises one or more deformable filaments. ### Claim 15 (depends on 10) A stent device according to claim 10 wherein the at least one deformable constraining member comprises one or more deformable bands. ### Claim 16 (depends on 10) A stent device according to claim 10 wherein the at least one deformable constraining member comprises at least one deformable sheaths. ### Claim 17 (depends on 16) A stent device according to claim 16 wherein the at least one deformable sheath comprises an inner polymer layer and an outer polymer and wherein the least one self-expanding stent member is positioned between the inner and outer polymer layers. ### Claim 18 (depends on 16) A stent device according to claim 16 wherein the at least one deformable sheath has perforations formed therein. ### Claim 19 (depends on 18) A stent device according to claim 18 wherein the size, shape, number and location of the perforations are selected to provide desired amounts of flexibility and diametric constraint. ### Claim 20 (depends on 18) A stent device according to claim 18 wherein the perforations are round. ### Claim 21 (depends on 18) A stent device according to claim 18 wherein the perforations are polygonal. ### Claim 22 (depends on 10) A stent device according to claim 10 wherein the at least one deformable constraining member is formed at least in part by a deformable metal or polymer. ### Claim 23 (depends on 22) A stent device according to claim 22 wherein the pressure deformable metal or polymer is selected from the group consisting of: PTFE, ePTFE, polyurethane, stainless steel or nickel-titanium. ### Claim 24 (depends on 10) A stent device according to claim 10 wherein the at least one self-expanding stent member comprises a plurality of self-expanding ring members and wherein the at least one deformable constraining member comprises a plurality of deformable constraining members that, in addition to providing diametric constraint, connect the plurality of self-expanding ring members to one another in series. ### Claim 25 (depends on 24) A stent device according to claim 24 wherein the plurality of self-expanding ring members comprise zig-zag rings having apices and wherein, in addition to providing diametric constraint, the deformable constraining members connect apices of one self-expanding zig-zag ring member to apices of another self-expanding zig-zag ring member. ### Claim at position 26 26-62. (canceled)