# US 2019/0167406 A1 · Methods of treating intracerebral hemorrhages using cyclical aspiration patterns

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- Number: US 2019/0167406 A1
- Document ID: US20190167406A1
- Status: Published application
- Kind: A1
- Application number: 16/241,611
- Filed: 2019-01-07
- Published: 2019-06-06
- Earliest claimed: 2016-02-16
- Assignees: Insera Therapeutics, Inc.
- Applicants: Insera Therapeutics, Inc.
- Inventors: Vallabh Janardhan; Vikram Janardhan
- Web page: https://patentgrep.com/patent/US20190167406A1

## CPC

- A61B 17/12113: {within an aneurysm}
- A61B 17/0057: {Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009)}
- A61B 17/12109: {in a blood vessel}
- A61B 17/12122: {within the heart (for closing a cardiac septal defect A61B17/0057)}
- A61B 17/12163: {having a string of elements connected to each other}
- A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61B 17/22: Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B 17/22031: {Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence)}
- A61B 17/22032: {having inflatable gripping elements (balloon catheters A61M25/10)}
- A61B 17/221: Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)}
- A61B 17/32056: {Surgical snare instruments (for removing or smashing calculi A61B2017/2212; tonsillotomes A61B17/26)}
- A61B 17/3207: Atherectomy devices {working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions (A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016)}
- A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers}
- A61F 2/013: {Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting}
- A61F 2/07: Stent-grafts
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61F 2/856: Single tubular stent with a side portal passage
- A61F 2/90: characterised by a net-like or mesh-like structure
- A61M 1/74: {Suction control (underwater drainage A61M1/61)}
- A61M 1/742: {by changing the size of a vent (A61M1/7411 takes precedence)}
- A61M 1/75: {Intermittent or pulsating suction (A61M1/63, A61M1/772 take precedence)}
- A61M 1/76: {Handpieces (specially for suction-irrigation A61M1/774, aspiration tips A61M1/84)}
- A61M 1/84: {Drainage tubes; Aspiration tips (for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32)}
- A61M 25/0023: {by the form of the lumen, e.g. cross-section, variable diameter}
- A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00})
- A61M 29/00: Dilators with or without means for introducing media, e.g. remedies
- B23K 26/083: {Devices involving movement of the workpiece in at least one axial direction}
- B23K 26/14: using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor (B23K26/12 takes precedence)
- B23K 26/142: for the removal of by-products
- B23K 26/1435: {involving specially adapted flow-control means}
- B23K 26/146: the fluid stream containing a liquid
- B23K 26/20: Bonding (soldering by means of radiant energy B23K1/005)
- B23K 26/38: by boring or cutting
- B26F 3/004: {by means of a fluid jet (methods for use of abrasive blasting for cutting B24C1/045; guns for abrasive fluid jets B24C5/02; perforating by non-mechanical means, e.g. by fluid jet B26F1/26)}
- D04C 1/06: Braid or lace serving particular purposes
- D04C 3/48: Auxiliary devices
- A61B 17/12177: {comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated}
- A61B 2017/00154: {pulsed}
- A61B 2017/00159: {Pulse shapes}
- A61B 2017/00185: {Means for setting or varying the pulse height}
- A61B 2017/00199: {with a console, e.g. a control panel with a display}
- A61B 2017/00309: {Cut-outs or slits}
- A61B 2017/00526: {Methods of manufacturing}
- A61B 2017/00575: {for closure at remote site, e.g. closing atrial septum defects}
- A61B 2017/00592: {Elastic or resilient implements}
- A61B 2017/00606: {Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening}
- A61B 2017/00641: {for closing fistulae, e.g. anorectal fistulae}
- A61B 2017/00867: {shape memory effect}
- A61B 2017/1205: {Introduction devices}
- A61B 2017/12054: {Details concerning the detachment of the occluding device from the introduction device}
- A61B 2017/22001: {Angioplasty, e.g. PCTA}
- A61B 2017/22002: {preventing restenosis}
- A61B 2017/22034: {for gripping the obstruction or the tissue part from inside}
- A61B 2017/22035: {for retrieving or repositioning foreign objects}
- A61B 2017/22067: {Blocking; Occlusion (A61B2017/22054 takes precedence)}
- A61B 2017/22079: {with suction of debris}
- A61B 2090/061: {for measuring dimensions, e.g. length}
- A61B 2090/3966: {Radiopaque markers visible in an X-ray image}
- A61B 2217/005: with suction drainage system
- A61F 2002/016: {made from wire-like elements}
- A61F 2002/018: {made from tubes or sheets of material, e.g. by etching or laser-cutting}
- A61F 2002/061: {provided with means for allowing access to secondary lumens}
- A61F 2002/068: {Modifying the blood flow model, e.g. by diffuser or deflector}
- A61F 2002/823: {Stents, different from stent-grafts, adapted to cover an aneurysm}
- A61F 2210/0014: using shape memory or superelastic materials, e.g. nitinol
- A61F 2230/001: Figure-8-shaped, e.g. hourglass-shaped
- A61F 2230/0015: Kidney-shaped, e.g. bean-shaped
- A61F 2230/0019: rectangular
- A61F 2230/0069: cylindrical
- A61F 2230/0071: spherical
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0017: differing in yarn density
- A61F 2250/0023: differing in porosity
- A61F 2250/0032: differing in radiographic density
- A61F 2250/0039: differing in diameter
- A61F 2250/0097: Visible markings, e.g. indicia
- A61F 2250/0098: radio-opaque, e.g. radio-opaque markers
- A61M 1/81: {Piston pumps, e.g. syringes}
- A61M 1/82: {Membrane pumps, e.g. bulbs}
- A61M 2025/0042: {Microcatheters, cannula or the like having outside diameters around 1 mm or less}
- A61M 2202/06: Solids
- A61M 2205/3561: local, e.g. within room or hospital
- A61M 2205/50: with microprocessors or computers
- A61M 2207/10: Device therefor
- A61M 2210/12: Blood circulatory system
- D10B 2403/0333: with tubular portions of variable diameter or distinct axial orientation
- D10B 2509/06: Vascular grafts; stents
- Y10T 29/49913: by constricting outer annulus
- Y10T 29/49995: Shaping one-piece blank by removing material
- Y10T 82/2521: Bar feeder
- Y10T 137/8376: Combined
- Y10T 137/85954: Closed circulating system
- Y10T 156/10: Methods of surface bonding and/or assembly therefor
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B23K: SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B26F: PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING (marking-out, perforating or making buttonholes A41H25/00; shoemaking A43D; surgery A61B; punching metal B21D; drilling metal B23B; cutting of metal by applying heat locally, e.g. flame cutting, B23K; cutting by abrasive fluid jets B24C5/02; details common to machines for severing B26D; drilling wood B27C; drilling stone B28D; working of plastics or substances in a plastic state B29; making boxes, cartons, envelopes or bags, of paper or similarly worked materials, e.g. metal foil, B31B; of glass C03B; of leather C14B; of textile materials D06H; for light guides G02B6/25; of tickets G07B)
- D04C: BRAIDING OR MANUFACTURE OF LACE, INCLUDING BOBBIN-NET OR CARBONISED LACE; BRAIDING MACHINES; BRAID; LACE (machines for making soles from strips of material A43D29/00; cane working B27J1/00)
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

An aspiration system includes a pump and a control system in communication with the pump. The control system includes a microcontroller, an antenna configured to receive a signal, and a pump control board in communication with the microcontroller. The antenna is in communication with the microcontroller. Upon receiving the signal, the pump control board operates the pump to create negative pressure according to the signal.

## Claims

### Claim 1

A method of treating an intracerebral hemorrhage using a repetitive cyclical pattern for aspiration, the method comprising:
inserting a distal end of a single-lumen cannula through a burr-hole in a skull;
choosing the cyclical pattern from a plurality of provided cyclical patterns or customizing the cyclical pattern, the cyclical pattern comprising repetition of a first suction level, a second suction level different than the first suction level, and a third suction level different than the first suction level and the second suction level, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern; and
aspirating blood through the cannula according to the chosen cyclical pattern by negative suction from a pump.

### Claim 2 (depends on 1)

The method of claim 1, wherein the cyclical pattern comprises a crescendo suction pattern.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cyclical pattern comprises a diminuendo suction pattern.

### Claim 4 (depends on 1)

The method of claim 1, wherein the cannula is configured to be inserted through a port of a neuro-endoscope.

### Claim 5

A method of treating an intracerebral hemorrhage using a repetitive cyclical pattern for aspiration, the method comprising:
inserting a distal end of a cannula through a burr-hole in a skull;
selecting the cyclical pattern from a plurality of provided cyclical patterns or customizing the cyclical pattern, the cyclical pattern comprising repetition of a first suction level and a second suction level different than the first suction level, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern; and
aspirating blood through the cannula according to the selected cyclical pattern by negative suction from a pump.

### Claim 6 (depends on 5)

The method of claim 5, wherein the cyclical pattern comprises a third suction level different than the first suction level and the second suction level.

### Claim 7 (depends on 5)

The method of claim 5, wherein the cyclical pattern comprises a crescendo suction pattern.

### Claim 8 (depends on 5)

The method of claim 5, wherein the cyclical pattern comprises a diminuendo suction pattern.

### Claim 9 (depends on 5)

The method of claim 5, wherein the cannula comprises a single lumen cannula.

### Claim 10 (depends on 5)

The method of claim 5, wherein the cannula is configured to be inserted through a port of a neuro-endoscope.

### Claim 11 (depends on 5)

The method of claim 5, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern, and wherein the cannula comprises a single lumen cannula.

### Claim 12

A method of treating an intracerebral hemorrhage using a repetitive cyclical pattern for aspiration, the method comprising:
inserting a distal end of a cannula through a burr-hole in a skull;
selecting the cyclical pattern from a plurality of provided cyclical patterns or customizing the cyclical pattern, the cyclical pattern comprising repetition of a first suction level and a second suction level different than the first suction level; and
aspirating blood through the cannula according to the selected cyclical pattern by an automated negative suction device.

### Claim 13 (depends on 12)

The method of claim 12, wherein the cyclical pattern comprises a third suction level different than the first suction level and the second suction level.

### Claim 14 (depends on 12)

The method of claim 12, wherein the cyclical pattern comprises a crescendo suction pattern.

### Claim 15 (depends on 12)

The method of claim 12, wherein the cyclical pattern comprises a diminuendo suction pattern.

### Claim 16 (depends on 12)

The method of claim 12, wherein the cannula comprises a single lumen cannula.

### Claim 17 (depends on 12)

The method of claim 12, wherein the cannula is configured to be inserted through a port of a neuro-endoscope.

### Claim 18 (depends on 12)

The method of claim 12, wherein the cannula is in communication with a switch.

### Claim 19 (depends on 12)

The method of claim 12, further comprising forming the burr-hole in the skull.

### Claim 20 (depends on 12)

The method of claim 12, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern, and wherein the cannula comprises a single lumen cannula.