# US 2019/0167163 A1 · Analyte sensors and methods of manufacturing same

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- Number: US 2019/0167163 A1
- Document ID: US20190167163A1
- Status: Published application
- Kind: A1
- Application number: 16/250,992
- Filed: 2019-01-17
- Published: 2019-06-06
- Earliest claimed: 2009-07-02
- Assignees: DexCom, Inc.
- Applicants: DexCom, Inc.
- Inventors: Peter C. Simpson; Robert J. Boock; Paul V. Neale; Sebastian Böhm; Matthew Wightlin; Jack Pryor; Jason Mitchell; Jeff Jackson; Kaushik Patel; Antonio C. Llevares
- Web page: https://patentgrep.com/patent/US20190167163A1

## CPC

- B23K 26/362: Laser etching
- A61B 5/14503: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence)}
- A61B 5/1451: {for interstitial fluid}
- A61B 5/14517: {for sweat}
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
- A61B 5/1473: invasive, e.g. introduced into the body by a catheter
- A61B 5/14865: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors}
- B05C 3/02: the work being immersed in the liquid or other fluent material
- B05C 3/10: the articles being moved through the liquid or other fluent material (conveying articles through baths B65G, e.g. B65G49/02)
- B05C 3/125: {the work being a web, band, strip or the like}
- A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors
- A61B 2562/0209: Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
- A61B 2562/043: in a linear array
- A61B 2562/125: characterised by the manufacture of electrodes
- B05C 5/0241: {for applying liquid or other fluent material to elongated work, e.g. wires, cables, tubes}
- B05D 1/18: performed by dipping
- B05D 3/06: by exposure to radiation (B05D3/02 takes precedence {; plasma treatment B05D3/141})
- B23K 26/0823: {Devices involving rotation of the workpiece}
- B29C 2791/009: Using laser
- C23C 2/00: Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor
- B23K: SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B05C: APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (spraying apparatus, atomising apparatus, nozzles B05B; plant for applying liquids or other fluent materials to objects by electrostatic spraying B05B5/08)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- C23C: COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL (making metal-coated products by extrusion B21C23/22; covering with metal by connecting pre-existing layers to articles, see the relevant places, e.g. B21D39/00, B23K; metallising of glass C03C; metallising mortars, concrete, artificial stone, ceramics or natural stone C04B41/00; enamelling of, or applying a vitreous layer to, metals C23D; treating metal surfaces or coating of metals by electrolysis or electrophoresis C25D; single-crystal film growth C30B; by metallising textiles D06M11/83; decorating textiles by locally metallising D06Q1/04)

## Abstract

Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

## Claims

### Claim at position 1

1-20. (canceled)

### Claim 21

A continuous analyte sensor configured for in vivo use, the continuous analyte sensor comprising:
an elongated conductive body comprising:
a substrate comprising a non-conductive polymeric material, wherein the substrate has a non-rectangular cross section;
a first electrode disposed on the substrate, wherein the first electrode is a working electrode;
a second electrode disposed on the substrate; and
a conductive pathway connecting the first electrode and the second electrode to sensor electronics; and
a membrane covering at least a portion of the working electrode.

### Claim 22 (depends on 21)

The continuous analyte sensor of claim 21, wherein the membrane comprises a polymer having a Shore hardness of from about 70A to about 55C.

### Claim 23 (depends on 21)

The continuous analyte sensor of claim 21, having a fatigue life of at least 1,000 cycles of flexing of from about 28° to about 110° at a bend radius of about 0.125-inches.

### Claim 24 (depends on 21)

The continuous analyte sensor of claim 21, which is configured for multi-axis bending.

### Claim 25 (depends on 24)

The continuous analyte sensor of claim 24, wherein the multi-axis bending is associated with flexing in at least three directions.