# US 2019/0167133 A1 · Wireless biological interface platform > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2019/0167133 A1 - Document ID: US20190167133A1 - Status: Published application - Kind: A1 - Application number: 16/314,344 - Filed: 2017-06-15 - Published: 2019-06-06 - Earliest claimed: 2016-06-15 - Assignees: Pluri, Inc. - Applicants: Pluri, Inc. - Inventors: David Frausto Pena - Web page: https://patentgrep.com/patent/US20190167133A1 ## CPC - A61B 5/0031: {Implanted circuitry} - A61B 5/24: Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof - A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)} - A61B 5/378: Visual stimuli - A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)} - A61B 5/7225: {Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316)} - A61B 2503/40: Animals - A61B 2560/0209: adapted for power saving - A61B 2560/0219: of externally powered implanted units - A61B 2560/045: with a separable interface unit, e.g. for communication - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A biological interface platform may include a WGPU customized for biological implantation in a living organism. The WGPU may be connected to modular probes, which may also be implanted and integrated together via software. The biological interface platform may be designed for the recording and/or transmission of biological information to and/or from a subject via a wireless interface and integration of that information across a software workspace. ## Claims ### Claim 1 A system, comprising: a plurality of modular probes; at least one wireless general processing unit (WGPU) operably connected to the plurality of modular probes; at least one adapter for respective external hardware, the at least one behavioral adapter configured to relay information from the respective external hardware; and a computing system running a biological interface application configured to process input from the at least one WGPU and the at least one adapter, the biological interface application configured to: coordinate digital information from the external hardware received via the at least one adapter with activity of the at least one WGPU configured with one or more of the plurality of modular probes, and receive and process the information relayed from the at least one adapter. ### Claim 2 (depends on 1) The system of claim 1, wherein the plurality of modular probes comprises at least one recording probe and at least one transmitting probe. ### Claim 3 (depends on 1) The system of claim 1, wherein the at least one WGPU is configured at runtime by the biological interface application. ### Claim 4 (depends on 1) The system of claim 1, wherein the computing system, via the biological interface application, is configured to control two or more WGPUs simultaneously, allowing multiple subjects to run simultaneously. ### Claim 5 (depends on 1) The system of claim 1, wherein the at least one WGPU comprises: a plurality of physical ports on an underside of the at least one WGPU; and a biocompatible enclosure that elevates the at least one WGPU to allow access to the physical ports, the biocompatible enclosure protecting electronic components of the at least one WGPU from exposure to interstitial fluid while reducing immune response from a subject when implanted. ### Claim 6 (depends on 5) The system of claim 5, wherein the at least one WGPU is coated in one or more biocompatible polymers. ### Claim 7 (depends on 1) The system of claim 1, wherein the at least one WGPU is configured to wait in a low power standby mode until a listening event occurs, at which point the at least one WGPU sets port parameters and initializes a loop until a user halts its operation. ### Claim 8 (depends on 1) The system of claim 1, wherein the biological interface application is configured to allow a user to set parameters of the at least one WGPU, the parameters comprising hardware configuration parameters, signal timing parameters, user-defined halt parameters, or any combination thereof. ### Claim 9 (depends on 1) The system of claim 1, wherein at least one of the plurality of modular probes receives power from one of the at least one WGPUs. ### Claim 10 (depends on 1) The system of claim 1, wherein at least one of the plurality of probes comprises: a surface mount light emitting diode (LED); a fiber core coupled to the surface mount LED; and a biocompatible enclosure in which the surface mount LED and fiber core are placed. ### Claim 11 (depends on 10) The system of claim 10, wherein the at least one of the plurality of probes is encased in a biocompatible polymer. ### Claim 12 (depends on 10) The system of claim 10, wherein the biocompatible enclosure comprises a removable implantation holder. ### Claim 13 (depends on 1) The system of claim 1, wherein at least one of the plurality of probes is a recording probe connected to a 32-channel electrode array, the recording probe comprising: a 32-channel multiplexer; and one or more amplifiers, wherein a signal received from the 32-channel electrode array is muxed by the multiplexer 832, amplified by the at least one amplifier, and sent to at least one of the at least one WGPUs for integration with other components of the system. ### Claim 14 (depends on 1) The system of claim 1, wherein the at least one adapter comprises: a step-down regulator configured to step-down a voltage of a signal from the respective external hardware to a lower voltage; a microcontroller configured to receive and process the stepped-down signal; and a USB-to-serial adapter configured to receive communications from the microcontroller and relay the communications to the biological interface application of the computing system. ### Claim 15 A wireless general processing unit (WGPU), comprising: a plurality of physical ports on an underside of the WGPU; and a biocompatible enclosure that elevates the WGPU to allow access to the physical ports, the biocompatible enclosure protecting electronic components of the WGPU from exposure to interstitial fluid while reducing immune response from a subject when implanted. ### Claim 16 (depends on 15) The WGPU of claim 15, wherein the WGPU is operably connected to a plurality of probes. ### Claim 17 (depends on 15) The WGPU of claim 15, wherein the WGPU is configured at runtime by a biological interface application. ### Claim 18 (depends on 15) The WGPU of claim 15, wherein the WGPU is configured to wait in a low power standby mode until a listening event occurs, at which point the WGPU sets port parameters and initializes a loop until a user halts its operation. ### Claim 19 (depends on 15) The WGPU of claim 15, wherein the WGPU is coated in one or more biocompatible polymers. ### Claim 20 An adapter, comprising: a step-down regulator configured to step-down a voltage of a signal from external hardware to a lower voltage; a microcontroller configured to receive and process the stepped-down signal; and a USB-to-serial adapter configured to receive communications from the microcontroller and relay the communications to a biological interface application of a computing system.