# US 2019/0167125 A1 · Inflow-based pulse wave velocity profiling along the aorta using magnetic resonance imaging

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2019/0167125 A1
- Document ID: US20190167125A1
- Status: Published application
- Kind: A1
- Application number: 15/828,900
- Filed: 2017-12-01
- Published: 2019-06-06
- Earliest claimed: 2017-12-01
- Assignees: Siemens Healthcare GmbH
- Applicants: Siemens Healthcare GmbH
- Inventors: Peter Speier; Kelvin Chow; Ning Jin
- Web page: https://patentgrep.com/patent/US20190167125A1

## CPC

- A61B 5/02125: {of pulse wave propagation time}
- A61B 5/02116: {of pulse wave amplitude (A61B5/02225 takes precedence)}
- A61B 5/0263: {using NMR}
- A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
- A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal}
- G01R 33/56325: {Cine imaging}
- G06T 1/0007: {Image acquisition}
- G06T 7/00: Image analysis
- G06T 12/00: Tomographic reconstruction from projections
- G16H 30/40: for processing medical images, e.g. editing
- A61B 2576/02: specially adapted for a particular organ or body part
- G01R 33/4835: {of multiple slices}
- G06T 2207/10088: Magnetic resonance imaging [MRI]
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

In a method and magnetic resonance (MR) apparatus for pulse wave velocity (PWV) measurement along the aorta of a subject using MR imaging, a multislice cardio synchronized segmented ciné MR data acquisition sequence is optimized in order to enhance inflow representation in the slice images, in order to make the multislice MR data acquisition sequence viable for clinical uses, so as to acquire intensity-based MR data from two transverse slices spaced from each other along the descending aorta. The respective intensities of relevant pixels in at least two respective slice images are analyzed in order to identify the arrival of a pulse wave in the respective slices by the onset of flow enhancement in the slices, represented by intensity changes in the pixels. From the onset of flow enhancement in the respective slice images, PWV is calculated. An electronic signal representing the calculated PWV is then provided from a computer.

## Claims

### Claim 1

A method for pulse wave velocity (PWV) measurement along the aorta of a subject, using magnetic resonance (MR) imaging, said method comprising:
using a control computer to operate an MR data acquisition scanner, while a subject is situated in the scanner, in order to acquire intensity-based MR data respectively from at least two transverse slices spaced from each other along the descending aorta, by executing a multislice cardio synchronized segmented ciné MR data acquisition sequence;
using a reconstruction computer to reconstruct an MR slice image, composed of pixels, of each of said at least two slices from the MR data acquired therefrom with said sequence, each of said pixels exhibiting an intensity value in respective MR slice images;
providing said MR slice images to an analysis computer and using said analysis computer to detect arrival of a pulse wave respectively in different slices from onset flow enhancement based on intensity values of relevant pixels derived respectively from at least two of said MR slice images;
in said analysis computer, calculating PWV from said arrival of said pulse wave respectively in said at least two of said MR slice images; and
providing an electronic output from the analysis computer that represents the calculated PWV.

### Claim 2 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to execute said multislice cardio synchronized segmented ciné MR data acquisition sequence as a simultaneous multi-slice MR data acquisition sequence.

### Claim 3 (depends on 2)

A method as claimed in claim 2 comprising using a GRE SMS 2 sequence as said simultaneous multi-slice cardio synchronized segmented ciné MR data acquisition sequence.

### Claim 4 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence with multiple slices being acquired interleaved.

### Claim 5 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence over multiple respiratory cycles of the subject.

### Claim 6 (depends on 5)

A method as claimed in claim 5 comprising operating said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence over said multiple respiratory cycles of the subject while the subject is freely breathing.

### Claim 7 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to repeat said multi-slice cardio synchronized segmented ciné MR data acquisition sequence multiple times in order to acquire slice images along respectively different positions of the descending aorta in the respective repetitions, and, from the MR slices obtained at said different positions in said multiple repetitions, generating a PWV profile in the descending aorta.

### Claim 8 (depends on 1)

A method as claimed in claim 1 comprising using said PWV profile in said analysis computer to identify at least one of local vessel stiffness of the subject, windpipe function of the subject, reflection sites in the subject, and an apparent age of vessels in the subject.

### Claim 9 (depends on 1)

A method as claimed in claim 1 comprising acquiring said intensity-based MR data from at least two transverse slices that are spaced from each other along the descending aorta in a spacing range between 100 mm and 400 mm.

### Claim 10 (depends on 1)

A method as claimed in claim 1 comprising acquiring said intensity-based MR data from said at least two transverse slices with an in-plane resolution in a range between 4 mm and 10 mm.

### Claim 11 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to excite nuclear spins in the respective at least two transverse slices by radiating a radio frequency pulse with a flip angle of approximately 30°.

### Claim 12 (depends on 1)

A method as claimed in claim 1 comprising operating said MR data acquisition scanner to excite nuclear spins in the respective at least two transverse slices, and to acquire said intensity-based MR data respectively from said at least two transverse slices, with a repetition time that is at least as low as 2 ms.

### Claim 13

A magnetic resonance (MR) apparatus for pulse wave velocity (PWV) measurement along the aorta of a subject using MR imaging, said MR apparatus comprising:
an MR data acquisition scanner;
a control computer configured to operate said MR data acquisition scanner, while a subject is situated in the scanner, in order to acquire intensity-based MR data respectively from at least two transverse slices spaced from each other along the descending aorta, by executing a multislice cardio synchronized segmented ciné MR data acquisition sequence;
a reconstruction computer configured to reconstruct an MR slice image, composed of pixels, of each of said at least two slices from the MR data acquired therefrom with said sequence, each of said pixels exhibiting an intensity value in respective MR slice images;
an analysis computer provided with said MR images to an analysis computer said analysis computer being configured to detect arrival of a pulse wave respectively in different slices from onset flow enhancement based on intensity values of relevant pixels derived respectively from at least two of said MR slice images;
said analysis computer being configured to calculate PWV from said arrival of said pulse wave respectively in said at least two of said MR slice images; and
said analysis computer being configured to provide an electronic output from the analysis computer that represents the calculated PWV.

### Claim 14 (depends on 13)

An MR apparatus as claimed in claim 13 wherein said control computer is configured to operate said MR data acquisition scanner to execute said multislice cardio synchronized segmented ciné MR data acquisition sequence as a simultaneous multi-slice MR data acquisition sequence.

### Claim 15 (depends on 14)

An MR apparatus as claimed in claim 14 wherein said control computer is configured to use a GRE SMS 2 sequence as said simultaneous multi-slice cardio synchronized segmented ciné MR data acquisition sequence.

### Claim 16 (depends on 13)

An MR apparatus as claimed in claim 13 wherein said control computer is configured to operate said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence with multiple slices being acquired interleaved.

### Claim 17 (depends on 13)

An MR apparatus as claimed in claim 13 wherein said control computer is configured to operate said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence over multiple respiratory cycles of the subject.

### Claim 18 (depends on 13)

An MR apparatus as claimed in claim 13 wherein said control computer is configured to operate said MR data acquisition scanner to execute said multi-slice cardio synchronized segmented ciné MR data acquisition sequence over said multiple respiratory cycles of the subject while the subject is freely breathing.

### Claim 19 (depends on 13)

An MR apparatus as claimed in claim 13 wherein said control computer is configured to operate said MR data acquisition scanner in order to repeat said multi-slice MR cardio synchronized segmented ciné MR data acquisition sequence so as to acquire slice images along respectively different positions of the descending aorta in the respective petitions, and, from the MR slices obtained at said different positions, generating a PWV profile in the descending aorta.

### Claim 20 (depends on 19)

An MR apparatus as claimed in claim 19 comprising using said PWV profile in said analysis computer to identify at least one of local vessel stiffness of the subject, windpipe function of the subject, reflection sites in the subject, and an apparent age of vessels in the subject.

### Claim 21 (depends on 13)

An MR apparatus as claimed in claim 13 comprising acquiring said intensity-based MR data from at least two transfer slices that are spaced from each other along the descending aorta in a spacing range between 100 mm and 400 mm.

### Claim 22 (depends on 13)

An MR apparatus as claimed in claim 13 comprising acquiring said intensity-based MR data from said at least two transfer slices with an in-plane resolution in a range between 4 mm and 10 mm.

### Claim 23 (depends on 13)

An MR apparatus as claimed in claim 13 comprising operating said MR data acquisition scanner to excite nuclear spins in the respective at least two transverse slices by radiating a radio frequency pulse with a flip angle of approximately 30°.

### Claim 24 (depends on 13)

An MR apparatus as claimed in claim 13 comprising operating said MR data acquisition scanner to excite nuclear spins in the respective at least two transverse slices, and to acquire said intensity-based MR data respectively from said at least two transverse slices, with a repetition time that is at least as low as 2 ms.

### Claim 25

A non-transitory, computer-readable data storage medium encoded with programming instructions, said storage medium being loaded into a computer system of a magnetic resonance (MR) apparatus that comprises an MR data acquisition scanner, and said programming instructions causing said computer system to:
operate the MR data acquisition scanner, while a subject is situated in the scanner, in order to acquire intensity-based MR data respectively from at least two transverse slices spaced from each other along the descending aorta, by executing a multislice cardio synchronized segmented ciné MR data acquisition sequence;
reconstruct an MR slice image, composed of pixels, of each of said at least two slices from the MR data acquired therefrom with said sequence, each of said pixels exhibiting an intensity value in respective MR slice images;
detect arrival of a pulse wave respectively in different slices from onset flow enhancement based on intensity values of relevant pixels derived respectively from at least two of said MR slice images;
calculate PWV from said arrival of said pulse wave respectively in said at least two of said MR slice images; and
provide an electronic output from the computer system that represents the calculated PWV.