# US 2019/0166898 A1 · Lipid composition for use in infants and young children for promoting gut comfort and optimal fat and calcium absorption

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- Number: US 2019/0166898 A1
- Document ID: US20190166898A1
- Status: Published application
- Kind: A1
- Application number: 16/321,559
- Filed: 2017-07-28
- Published: 2019-06-06
- Earliest claimed: 2016-08-05
- Assignees: Nestec S.A.
- Applicants: Nestec S.A.
- Inventors: Frederic Destaillats; Valerie Petit
- Web page: https://patentgrep.com/patent/US20190166898A1

## CPC

- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A23L 33/12: Fatty acids or derivatives thereof
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2250/1886: Stearic acid
- A23V 2250/206: Bacterial extracts
- A23V 2250/502: Gums
- A23V 2250/54246: Casein
- A23V 2250/54252: Whey protein
- A23V 2250/55: Peptide, protein hydrolysate
- A23V 2250/612: Lactose
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to a nutritional composition, for infants and young children (about 12 to 36 months) in which the sum of the triacylglycerols (TAG) sn-1(3) palmitic acid (PA), myristic acid (MA) and stearic acid (SA) constitutes less than 13.0% of the TAG. The composition promotes absorption of fatty acids and calcium in the gut, improves gut comfort, decreases abdominal pain associated with hard stool formation, promotes regular bowel movements and reduces the incidence and severity of constipation in infants and young children (up to the age of about three years old). The composition also promotes bone mineralization, increasing bone strength and bone mineral density.

## Claims

### Claim 1

A nutritional composition for infants or young children comprising protein, carbohydrates and lipids, the lipids comprising fatty acid (FA) triacylglycerols (TAG), the fatty acid TAG comprising stearic, palmitic and myristic esters, wherein the sum of the amount of stearic, palmitic and myristic esters at the sn-1(3) position of the TAG is less than 13.0% (w/w) of TAG and the myristic acid represents up to 3.6% of the total FA, the palmitic acid represents up to 11.1% of the total FA and stearic acid represents up to 4.6% of the total FA (w/w).

### Claim 2 (depends on 1)

Composition of claim 1 wherein the sum of the total palmitic, and myristic, and stearic esters of the TAG is less than 19.3% (w/w) of total fatty acid TAG.

### Claim 3 (depends on 1)

Composition of claim 1 wherein the carbohydrates comprise 99% to 100% of lactose.

### Claim 4 (depends on 1)

Composition of claim 1 wherein the amount of the protein in the composition is less than or equal to 3.0 or 2.1 g protein/100 kcal.

### Claim 5 (depends on 1)

Composition of claim 1 wherein the amount of the protein in the composition is less than or equal to 2.1 g protein/100 kcal of composition.

### Claim 6 (depends on 1)

Composition of claim 1 wherein the protein is a mixture of whey protein and casein wherein the ratio of whey protein to casein is between 50:50 and 80:20.

### Claim 7 (depends on 1)

Composition of claim 1 wherein the protein is partially hydrolyzed.

### Claim 8 (depends on 1)

Composition of claim 1 wherein the composition also comprises at least one prebiotics.

### Claim 9 (depends on 1)

Composition of claim 1 wherein the composition also comprises probiotics.

### Claim 10 (depends on 1)

Composition of claim 1 wherein the lipids are selected from the group consisting of DHA, ARA and EPA.

### Claim 11

A method for reducing digestive discomfort and/or reducing abdominal pain and/or reducing the incidence and/or severity of colic and/or reducing the incidence and/or severity of constipation in infants or young children comprising administering to an infant in need of same a composition comprising protein, carbohydrates and lipids, the lipids comprising fatty acid (FA) triacylglycerols (TAG), the fatty acid TAG comprising stearic, palmitic and myristic esters, wherein the sum of the amount of stearic, palmitic and myristic esters at the sn-1(3) position of the TAG is less than 13.0% (w/w) of TAG and the myristic acid represents up to 3.6% of the total FA, the palmitic acid represents up to 11.1% of the total FA and stearic acid represents up to 4.6% of the total FA (w/w).

### Claim 12 (depends on 11)

The method of claim 11 wherein the reduction in digestive discomfort and/or abdominal pain and/or reduction in the incidence and severity of colic and/or reduction of the incidence and/or severity of constipation comprises reducing the stool hardness.

### Claim 13

(canceled)

### Claim 14 (depends on 11)

The method of claim 11 for use in increasing bone mineralization, increasing bone strength, and/or increasing bone mineral density in infants or young children.

### Claim 15

Method for improving calcium homeostasis and calcium and lipid absorption, increasing calcium and lipid retention, and/or in reducing the formation of palmitic acid or stearic acid or myristic acid soaps in infants or young children comprising the steps of administering to an infant or young child in need of same comprising protein, carbohydrates and lipids, the lipids comprising fatty acid (FA) triacylglycerols (TAG), the fatty acid TAG comprising stearic, palmitic and myristic esters, wherein the sum of the amount of stearic, palmitic and myristic esters at the sn-1(3) position of the TAG is less than 13.0% (w/w) of TAG and the myristic acid represents up to 3.6% of the total FA, the palmitic acid represents up to 11.1% of the total FA and stearic acid represents up to 4.6% of the total FA (w/w).
