# US 2019/0166846 A1 · Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers

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- Number: US 2019/0166846 A1
- Document ID: US20190166846A1
- Status: Published application
- Kind: A1
- Application number: 16/272,579
- Filed: 2019-02-11
- Published: 2019-06-06
- Earliest claimed: 2000-11-08
- Assignees: FXS Ventures, LLC
- Applicants: FXS Ventures, LLC
- Inventors: Francis X. Smith
- Web page: https://patentgrep.com/patent/US20190166846A1

## CPC

- A01N 47/44: Guanidine; Derivatives thereof
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61L 12/141: {Biguanides, e.g. chlorhexidine}
- A61L 12/142: {Polymeric biguanides}
- A61L 12/143: {Quaternary ammonium compounds}
- A61L 12/145: {Polymeric quaternary ammonium compounds}
- C11D 3/0078: {Compositions for cleaning contact lenses, spectacles or lenses}
- C11D 3/046: {Salts}
- C11D 3/2065: {Polyhydric alcohols}
- C11D 3/221: {Mono, di- or trisaccharides or derivatives thereof}
- C11D 3/3703: {Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds}
- C11D 3/48: Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL

## Abstract

The present invention relates to an ophthalmic solution comprising 0.00001 to 10.0 weight percent of a simple saccharide, at least 0.00001 weight percent of a preservative, and not more than about 0.2 percent by weight chloride. The simple saccharide is chosen from the group consisting of: inositol; mannitol; sorbitol; sucrose; dextrose; glycerin; propylene glycol; ribose; triose; tetrose; erythrose; threose; pentose; arabinose; ribulose; xylose; xylulose; lyxose; hexose; allose; altrose; fructose; galactose; glucose; gulose; idose; mannose; sorbose; talose; tagatose; adlose; ketose; heptose; sedoheptulose; monosaccharides; disaccharides; sugar alcohols; xylitol; and polyol.

## Claims

### Claim 1

A method for providing an ophthalmic solution comprising:
contacting an eye with a single-part solution comprising 0.00001 to 10.0 weight percent of a simple saccharide that is a tetrose;
at least 0.00001 weight percent of a preservative with a structure given by:
wherein n is a number between 1 and 500 and Z is a divalent bridging group; and
wherein the concentration of chloride in said solution is not more than 0.2 percent by weight.

### Claim 2 (depends on 1)

The method as recited in claim 1, wherein the concentration of the preservative is between 0.1 and 100 parts per million.

### Claim 3 (depends on 2)

The method as recited in claim 2, wherein the preservative is polyhexamethylene biguanide.

### Claim 4 (depends on 1)

The method as recited in claim 1, wherein the single-part solution further comprises a physiologically compatible buffer.

### Claim 5 (depends on 4)

The method as recited in claim 4, wherein the physiologically compatible buffer is selected from a group consisting of: phosphate, bicarbonate, citrate, borate, ACES, acetate, BES, BICINE, BIS, BIS-Iris, BIS-Iris Propane, bicarbonate, histidine, HEPES, Iris, HEPPS, imidazole, MES, MOPS, PIPES, TAPS, TES, glycine, tromethamine, and Tricine.

### Claim 6 (depends on 1)

The method as recited in claim 1, wherein the single-part solution further comprises a wetting agent.

### Claim 7 (depends on 6)

The method as recited in claim 6, wherein the wetting agent is selected from a group consisting of: polysorbate surfactants, polyoxyethylene surfactants, polyethoxylated glycerides, phosphonates, saponins and polyethoxylated castor oils.

### Claim 8 (depends on 1)

The method as recited in claim 1, wherein the single-part solution further comprises a sequestering agent.

### Claim 9 (depends on 8)

The method as recited in claim 8, wherein the sequestering agent selected from a group consisting of: ethylenediaminetetraacetic acid, phosphonates, citrate, gluconate, nitrilotriacetic acid, diethylenetriamine pentaacetic acid, hydroxyethylethylenediaminetiacetic acid, 1,2-diaminocyclohexanetetraacetic acid, ethylene glycol bis (beta-aminoethyl ether), tetraacetic acid (EGTA), aminodiacetic acid, hydroxyethylamino diacetic acid, tartarate, and water-soluble salts thereof.

### Claim 10 (depends on 1)

The method as recited in claim 1, wherein the simple saccharide is a tetrose.

### Claim 11 (depends on 1)

The method as recited in claim 1, wherein the simple saccharide is erythrose or threose.

### Claim 12

A method for providing an ophthalmic solution comprising:
contacting an eye with a single-part solution comprising 0.00001 to 10.0 weight percent of a simple saccharide that is a pentose;
at least 0.00001 weight percent of a preservative with a structure given by:
wherein n is a number between 1 and 500 and Z is a divalent bridging group; and
wherein the concentration of chloride in said solution is not more than 0.2 percent by weight.

### Claim 13 (depends on 12)

The method as recited in claim 12, wherein the simple saccharide is a pentose.

### Claim 14 (depends on 12)

The method as recited in claim 12, wherein the simple saccharide is arabinose, ribulose, xylose, xylulose, lyxose or xylitol.

### Claim 15

A method for providing an ophthalmic solution comprising:
contacting an eye with a single-part solution comprising 0.00001 to 10.0 weight percent of a simple saccharide that is a hextose;
at least 0.00001 weight percent of a preservative with a structure given by:
wherein n is a number between 1 and 500 and Z is a divalent bridging group; and
wherein the concentration of chloride in said solution is not more than 0.2 percent by weight.

### Claim 16 (depends on 15)

The method as recited in claim 15, wherein the simple saccharide is a ketose.

### Claim 17 (depends on 15)

The method as recited in claim 15, wherein the simple saccharide is a hextose.

### Claim 18 (depends on 15)

The method as recited in claim 15, wherein the simple saccharide is inositol, ribose, allose, altrose, fructose, galactose, glucose, gulose, idose, mannose, sorbose, talose or tagatose.