Systems and methods for adjusting a basal/bolus ratio in an insulin regimen

A device for adjusting a basal/bolus ratio in a standing insulin regimen for a subject, wherein the device comprises one or more processors and a memory, the memory storing instructions that, when executed by the one or more processors, perform a method of:

• obtaining the standing insulin regimen for the subject, wherein the standing insulin regimen for the subject comprises a daily total insulin medicament, the daily total insulin medicament is satisfied by a combination of a daily amount of a basal insulin medicament and a daily amount of a bolus insulin medicament specified by the standing insulin regimen for the subject that is administered by one or more insulin pens, and the daily amount of basal insulin medicament and the daily amount of bolus insulin medicament defines an initial basal/bolus ratio between the daily amount of basal insulin medicament and the daily amount of bolus insulin medicament;
• obtaining a first data set, the first data set comprising a plurality of glucose measurements of the subject over a time course, and, for each respective glucose measurement in the plurality of glucose measurements, a timestamp representing when the respective measurement was made;
• identifying one or more fasting events in the time course;
• computing a respective temporal glucose gradient, for each respective fasting event in the one or more fasting events, using the glucose measurements of the subject obtained from the first data set that are in a time period of the respective fasting event;
• using the gradient of each fasting event in the one or more fasting events to determine whether to make a recommended adjustment to the basal/bolus ratio for the subject without change to the daily total insulin medicament;
• and
• communicating the recommended adjustment to the basal/bolus ratio, when the determination is made to make the recommended adjustment to the basal/bolus ratio for the subject, to:
• (i) the subject for manual adjustment of the basal/bolus ratio in the standing insulin regimen,
• (ii) each insulin pen in the one or more insulin pens charged with delivering the standing insulin regimen to the subject, as dosage adjustment instructions, or
• (iii) a health care practitioner associated with the subject.