Systems and methods for quantification and presentation of medical risk arising from unknown factors
AssigneeYouscript Inc.
InventorsHoward C. Coleman, Robert D. Patterson, Jessica Oesterheld, Rajeev V. Pany, Kristine Ashcraft
Life of this patent
Estimating the term…
Abstract
Example methods of quantifying known and unknown risks of an adverse drug event in an individual based on various factors are disclosed. In some embodiments, factors include known drug-drug interactions and unknown phenotypes of cytochromes. Quantification may be based on severity of the adverse drug event/and or probability of occurrence in some embodiments. Example methods of displaying the quantified risk are also disclosed. In one embodiment, the risk of individuals is aggregated to display the risk of a population.
Claims19
A method comprising:
- receiving, at a computing system, identification of at least one drug;
- selecting, using the computing system, certain factors affecting exposure of an individual to the at least one drug, wherein the certain factors include a genotype and one or more of hospital incident data, adverse event data, medical coding data, or combinations thereof, wherein at least one of the certain factors comprises known factors for the individual and at least one of the certain factors comprises unknown factors for the individual;
- quantifying, using the computing system, an expected effect on metabolism of the drug by the individual due to the known factors and the unknown factors;
- generating, using the computing system, a numerical representation of risk based at least in part on the expected effect;
- ranking, using the computing system, the individual based on the numerical representation of risk relative to a patient population;
- and
- displaying, using the computing system, the numerical representation of risk and the ranking in an interaction report.
The method of claim 7, further comprising displaying, using the comp in system, a graphical indicator that genetic testing is advised.
A non-transitory computer readable medium encoded with executable instructions for:
- receiving, at a computing system, identification of at least one drug;
- selecting, using the computing system, certain factors affecting exposure of an individual to the at least one drug, wherein the certain factors include a genotype and one or more of hospital incident data, adverse event data, medical coding data or combinations thereof, wherein at least one of the certain factors comprises known factors for the individual and at least one of the certain factors comprises unknown factors for the individual;
- quantifying, using the computing system, an expected effect on metabolism of the drug by the individual due to the known factors and the unknown factors;
- generating, using the computing system, a numerical representation of risk based at least in part on the expected effect;
- ranking, using the computing system, the individual based on the numerical representation of risk relative to a patient population;
- and
- displaying, using the computing system, the numerical representation of risk and the ranking in an interaction report.
Dependencies are inferred from the claim text.