Biomarkers signature discovery and selection

A method for discovering at least a biomarkers signature from biomarker data pools, the method comprising the steps of:

• i) Generating a set of signatures fuzzy logic and evolutionary algorithms, each signature reciting a determined number of biomarkers;
• ii) Selecting at least a target signature from said set of signatures by applying at least the following filters on said set of signatures:
• a) a performance filter comprising:
• setting a performance threshold for at least a performance criterion;
• removing signatures having a value below said performance threshold for said performance criteria;
• b) a frequency filter for sorting said set of signatures depending on the frequency of one biomarker within said set of signatures or the co-frequency of several biomarkers within the same signature among said set of signatures;
• and
• c) a dominance filter comprising:
• ranking the set of signatures depending on at least one performance criteria;
• computing a dominance value for each signature, the dominance value being the number of signatures with a superior ranking for said performance criteria;
• setting a dominance threshold and removing the signatures having a dominance value higher than said dominator threshold.